ArticleJournal of the American Heart Association2025
Temporal Changes in Epicardial Adipose Tissue and Left Atrial Substrate After Atrial Fibrillation Ablation: Implications for Procedural Success.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Reverse Cardiac and Epicardial Adipose Tissue Remodeling Following Catheter Ablation of Paroxysmal Atrial Fibrillation in HFpEF.Diagnostics (Basel, Switzerland) · 2026Article
- A New Paradigm for Atrial Fibrillation Ablation in Obesity Focusing on Substrate Remodeling and Patient-Centered Outcomes.Reviews in cardiovascular medicine · 2026Review
- Metabolic score for visceral fat and atrial fibrillation risk: a prospective study.BMC endocrine disorders · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGanglionated plexi (GPs) within epicardial adipose tissue (EAT) are involved in the initiation and maintenance of atrial fibrillation (AF), yet the effects of catheter ablation on EAT volume and GP activity remain unclear.
methodsA prospective 2-part study was conducted. Study 1 included 120 patients undergoing initial AF ablation, with pre- and 1-year postablation computed tomography used to assess changes in EAT and left atrial wall characteristics. Body composition, biomarkers, and echocardiographic variables were also evaluated. Study 2 included 20 patients undergoing redo ablation for recurrent AF, in whom vagal responses elicited by high-frequency stimulation in 5 major left atrial GP areas were compared.
resultsIn study 1, significant reductions in total EAT (median, 116 [interquartile range (IQR), 86-153] to 103 [IQR, 71-138] mL;
conclusionsPostablation maintenance of sinus rhythm was associated with a reduction in EAT volume. AF recurrence was associated with EAT expansion, compositional changes, and GP reactivation. Further investigation is needed to clarify clinical implications of these findings.
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