SynthesisJournal of the American Heart Association2025
Early Aortic Valve Replacement of Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials.
Synthesis in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early aortic valve intervention versus clinical surveillance in patients with asymptomatic severe aortic stenosis: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Time for Change: Strengthening Early Detection and Intervention Strategies to Improve Cardiovascular Health in Canada.CJC open · 2026Review
- Early Intervention Versus Watchful Waiting in Asymptomatic Severe Aortic Stenosis: Systematic Review and Meta-Analysis.JACC. Asia · 2026Article
- Categories of Aortic Stenosis: What's New and the Clinical Implications.Medicina (Kaunas, Lithuania) · 2026Review
- Physiologic Markers of Mortality in Acute Valve Syndrome: An Ischemic Physiology Score Stratifies Patient Risk.Structural heart : the journal of the Heart Team · 2026Article
- Impact of Acute Valve Syndrome on Outcomes of Aortic Valve Replacement for Aortic Stenosis.Journal of the American Heart Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsymptomatic severe aortic stenosis may lead to the progression to both symptoms and adverse outcomes if left untreated. The appropriate timing of intervention for these patients remains controversial, and any decision requires careful assessment.
methodsWe searched PubMed, Web of Science, EMBASE, and Cochrane Library for randomized controlled trials comparing early aortic valve replacement with conservative management in asymptomatic patients with severe aortic stenosis until December 2024. The primary efficacy outcome was a composite of all-cause mortality, hospitalization for cardiovascular causes, stroke, and myocardial infarction. We expressed outcome data as risk ratios (RRs) with 95% CIs.
resultsWe included 4 randomized controlled trials involving 1427 patients. Early aortic valve replacement significantly reduced the incidence of the composite outcome when compared with conservative management (29.2% versus 53.7%; RR, 0.56 [95% CI, 0.49-0.64]; I
conclusionsOur meta-analysis of randomized controlled trials showed that among patients with asymptomatic severe aortic stenosis, a strategy of early aortic valve interventions was superior to conservative treatments in reducing the primary composite outcome of all-cause mortality, hospitalization for cardiovascular causes, stroke, and myocardial infarction. However, significant differences in the rates of cardiac-specific mortality were not apparent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.