ArticlePsychological medicine2025
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.
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Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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3 citing papers in PubMed.
- Sex differences in the genetic and causal relationships between depression, smoking, and alcohol use: the role of socioeconomic status.Psychological medicine · 2026Article
- Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology.medRxiv : the preprint server for health sciences · 2026Article
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
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Authors and funding
67 authors.
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.ORCID 0000-0003-0394-777X
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Jared V BalbonaDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Alex P MillerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Alexander S HatoumDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Joseph D DeakDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Mariela JenningsDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
David A A BarangerDepartment of Psychological and Brain Sciences, Washington University in St Louis, Saint Louis, MO, USA.
Marco GalimbertiDepartment of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
Kittipong SanichwankulSuanprung Psychiatric Hospital, Chiang Mai, Thailand.
Thorgeir ThorgeirssondeCODE Genetics/Amgen, Sturlugata 8, IS-101, Reykjavik, Iceland.
Sarah M C ColbertDepartment of Genetics and Genomic Sciences, https://ror.org/04a9tmd77Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Keyrun AdhikariDepartment of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
Anna R DochertyDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Louisa DegenhardtNational Drug and Alcohol Research Centre, https://ror.org/03r8z3t63University of New South Wales, Sydney, Australia.
Tobias EdwardsDepartment of Psychology, https://ror.org/017zqws13University of Minnesota Twin Cities, Minneapolis, MN, USA.
Louis FoxDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Alexandros GiannelisDepartment of Psychology, https://ror.org/017zqws13University of Minnesota Twin Cities, Minneapolis, MN, USA.
Paul W JeffriesDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Tellervo KorhonenInstitute for Molecular Medicine Finland, https://ror.org/040af2s02University of Helsinki, Helsinki, Finland.
Claire L MorrisonDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Yaira Z NunezDepartment of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
Teemu PalviainenInstitute for Molecular Medicine Finland, https://ror.org/040af2s02University of Helsinki, Helsinki, Finland.
Mei-Hsin SuVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Pamela N Romero VillelaDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Emily A WilloughbyDepartment of Psychology, https://ror.org/017zqws13University of Minnesota Twin Cities, Minneapolis, MN, USA.
Stephanie M ZellersInstitute for Molecular Medicine Finland, https://ror.org/040af2s02University of Helsinki, Helsinki, Finland.
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Jadwiga BuchwaldInstitute for Molecular Medicine Finland, https://ror.org/040af2s02University of Helsinki, Helsinki, Finland.
William E CopelandDepartment of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, USA.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Naomi P FriedmanDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Ian R GizerDepartment of Psychological Sciences, https://ror.org/02ymw8z06University of Missouri, Columbia, MO, USA.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Ian B HickieBrain and Mind Institute, https://ror.org/0384j8v12University of Sydney, Sydney, NSW, Australia.
Jaakko KaprioInstitute for Molecular Medicine Finland, https://ror.org/040af2s02University of Helsinki, Helsinki, Finland.
Matthew C KellerDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
James J LeeDepartment of Psychology, https://ror.org/017zqws13University of Minnesota Twin Cities, Minneapolis, MN, USA.
Penelope LindQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Pamela A MaddenDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Hermine H M MaesVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Matt McGueDepartment of Psychology, https://ror.org/017zqws13University of Minnesota Twin Cities, Minneapolis, MN, USA.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Elliot C NelsonDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
John PearsonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Bernice PorjeszHenri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Health Science University, Brooklyn, NY, USA.
Michael C StallingsDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Scott VriezeDepartment of Psychology, https://ror.org/017zqws13University of Minnesota Twin Cities, Minneapolis, MN, USA.
Kirk C WilhelmsonDepartment of Neurology and Genetics and the Bowles Center of Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA.
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.
Raymond K WaltersAnalytic and Translational Genetics Unit, https://ror.org/002pd6e78Massachusetts General Hospital, Boston, MA, USA.
Renato PolimantiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Robert MalisonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Hang ZhouDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Kari StefanssondeCODE Genetics/Amgen, Sturlugata 8, IS-101, Reykjavik, Iceland.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Marc PotenzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Apiwat MutiranguraDepartment of Anatomy, Faculty of Medicine, https://ror.org/028wp3y58Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Vorasuk ShotelersukCenter of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, https://ror.org/028wp3y58Chulalongkorn University, Bangkok, Thailand.
Rasmon KalayasiriDepartment of Psychiatry, Epidemiology of Psychiatric Disorders and Mental Health Research Unit, Faculty of Medicine, https://ror.org/028wp3y58Chulalongkorn University, Bangkok, Thailand.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MTwin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5MThe Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MSex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0MPILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1999 to 2008
$12.6MGENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5MTHE GENETICS OF VULNERABILITY TO NICOTINE ADDICTIONSR01DA012854 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2000 to 2013
$10.4MA Developmental Model of Gene-Environment Interplay in SUDsU01DA024413 · NIDA · DUKE UNIVERSITY · PI COSTELLO, ELIZABETH JANE · 2007 to 2010
$7.7MThe development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6MVulnerability to Drug Abuse:Pathways to RecoveryR01DA011301 · NIDA · DUKE UNIVERSITY · PI COSTELLO, ELIZABETH JANE · 1997 to 2015
$7.3MGENETICS OF ADOLESCENT ANTISOCIAL DRUG DEPENDENCER01DA012845 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 2000 to 2012
$7.1MNCI NIH HHS P01 CA089392NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS N01 HG065403NHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NIAAA NIH HHS K01 AA031724NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R01 AA017444NIAAA NIH HHS R01 AA017535NIAAA NIH HHS R01 AA031176NIAAA NIH HHS R37 AA007728NIAAA NIH HHS R37 AA012502NIAAA NIH HHS U10 AA008401NIDA NIH HHS K01 DA051759NIDA NIH HHS K01DA051759NIDA NIH HHS K08 DA019951NIDA NIH HHS K24 DA032555NIDA NIH HHS P60 DA011015NIDA NIH HHS R00 DA023549NIDA NIH HHS R01 DA011301NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA013423NIDA NIH HHS R01 DA017305NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA019963NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA021913NIDA NIH HHS R01 DA024413NIDA NIH HHS R01 DA035804NIDA NIH HHS R56 DA012854NIDA NIH HHS RC2 DA028909NIDA NIH HHS U01 DA024413NIMH NIH HHS K01 MH093731NIMH NIH HHS K23 MH080230NIMH NIH HHS R01 MH048085NIMH NIH HHS R01 MH063671NIMH NIH HHS R01 MH063970NIMH NIH HHS R01 MH077874NIMH NIH HHS R01 MH130448NINR NIH HHS R90 NR021799Wellcome Trust
Abstract
backgroundGenetic research on nicotine dependence has utilized multiple assessments that are in weak agreement.
methodsWe conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared the results to other nicotine-related phenotypes.
resultsWe replicated the well-known association at the
conclusionsOur results suggest that combining the wide availability of diagnostic EHR data with nuanced criterion-level analyses of DSM tobacco use disorder may produce new insights into the genetics of this disorder.
Indexed as
Substance-Related DisordersTobacco Use DisorderAdultAlcoholismAsian PeopleBlack PeopleDiagnostic and Statistical Manual of Mental DisordersFemaleGenome-Wide Association StudyHumansMaleMiddle AgedNerve Tissue ProteinsPhenotypePolymorphism, Single NucleotideReceptors, NicotinicCHRNA5 protein, humanNerve Tissue ProteinsReceptors, Nicotinicaddictiongenome-wide association studynicotine dependencepolygenic riskpsychiatric disorders
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