ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Real-time NMR analysis of glutamine metabolism for screening anti-cancer agents in living cells.Magnetic resonance letters · 2027Article
- Isopsoralen Promotes Mandibular Fracture Healing by Regulating Autophagy.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Targeting a Shared Mitophagy Regulator: The SIRT1-FOXO3-DEPP1 Axis Underpins the Dual Bone and Brain Benefits of Total Flavonoids fromResearch (Washington, D.C.) · 2026Article
- Therapeutic potential of natural products from Traditional Chinese Medicine in the treatment of osteoporosis.Frontiers in pharmacology · 2026Review
- Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Human dental pulp stem cells (hDPSCs) are dental-derived mesenchymal stem cells with robust multipotent differentiation potentials, rendering them promising for bone tissue engineering. However, their differentiation relies on expensive, hard-to-control growth factors. Neoeriocitrin (Neo), a natural flavonoid, promotes cell proliferation and regulates alkaline phosphatase activities. However, Neo's effect on hDPSCs osteogenesis and bone regeneration is unknown. This study investigated Neo's impact on hDPSCs osteogenic differentiation and its mechanisms for bone regeneration. Neo effectively boosted hDPSCs osteogenic differentiation in vitro and facilitated bone regeneration in rat calvarial defects in vivo. Thermal proteome profiling revealed Neo directly binds Beclin1, validated by cellular thermal shift assay, molecular docking, and molecular dynamics. Neo stabilized Beclin1 by inhibiting ubiquitination-mediated degradation, increasing autophagy in Neo-treated hDPSCs. Furthermore, Neo-enhanced osteogenic differentiation is activated by the Beclin1 network, pivotal for bone regeneration. Elucidating the Neo-Beclin1 interaction provides insights into regulating hDPSCs differentiation and opens new avenues for enhancing bone regeneration strategies.
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Registered trials
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