Evidence map›Paper›PMID 40831212›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

LPS-Induced Mitochondrial Damage via SLC41A1-Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells.

Yuan Liu, Chenyu Song, Liyuan Zhang, Xue Han, Chaoyuan Li, Yanhong Yan, Ludan Xing, Mengting Si, Bo Yang, Lingyuan Cheng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan LiuShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.ORCID https://orcid.org/0009-0005-0038-319X
Chenyu SongShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Liyuan ZhangShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Xue HanShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Chaoyuan LiShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Implantology, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Yanhong YanShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Ludan XingShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Mengting SiShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Bo YangDepartment of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200023, China.
Lingyuan ChengShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Akimi MuramatsuShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
Beizhan JiangShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Pediatric Dentistry, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.ORCID https://orcid.org/0000-0002-0135-5917

Funding

National Natural Science Foundation of China 82301012Shanghai Hospital Development Center Foundation SHDC12023115
6 · The paper itself

Abstract

Although regenerative endodontics demonstrate promise for dental pulp regeneration, chronic inflammation often hinders the success. This study aims to explore the mechanism whereby lipopolysaccharide (LPS) induces dental pulp regeneration failure. Transcriptomic profiling of LPS-stimulated dental pulp stem cells (DPSCs) reveals dysregulated cation homeostasis and increased magnesium (Mg

Indexed as

Cation Transport ProteinsDental PulpLipopolysaccharidesMagnesiumMitochondriaPyroptosisStem CellsCells, CulturedHumansReactive Oxygen SpeciesCation Transport ProteinsLipopolysaccharidesMagnesiumReactive Oxygen Speciesdental stem cellmagnesium ionmitochondrial permeability transition porepyroptosissolute carrier family 41 member 1

Identifiers

PMID40831212
PMCPMC12622442

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.