Evidence map›Paper›PMID 40831202›Full record

ArticleHeadache2026

Pre-natal nutrition as risk factor for painful temporomandibular disorders and headaches in young adults.

Cristina Rocha Exposto, Mojdeh Mansoori, Bodil Hammer Bech, Anne Ahrendt Bjerregaard, Sjurdur Frodi Olsen, Lene Baad-Hansen

Abstract read
In one paragraph

Article in Headache, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cristina Rocha ExpostoSection for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Mojdeh MansooriSection for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-9026-7590
Bodil Hammer BechDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark.
Anne Ahrendt BjerregaardCenter for Clinical Research and Prevention, Copenhagen University Hospital, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Sjurdur Frodi OlsenBiobank, Congenital Disorders, and Vaccines Preparedness, Statens Serum Institute, Copenhagen, Denmark.
Lene Baad-HansenSection for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the relationship between prenatal nutrition and the development of painful temporomandibular disorders (p-TMD) and headaches in offspring during young adulthood.

backgroundp-TMD are a common source of chronic orofacial pain and are often comorbid with headaches. Dietary quality may influence chronic musculoskeletal pain, but its role on the development of p-TMD and headache is less known.

methodsThe study was conducted as a prospective longitudinal cohort study. Survey data from the Danish National Birth Cohort (DNBC) were analyzed. Data included prenatal nutritional information assessed using a healthy eating index (HEI) derived from a food frequency questionnaire collected between 1996 and 2002 and offspring's p-TMD and headache status at age 18-23 years, assessed in 2021. HEI was categorized into quartile levels of dietary quality. A total of 10,382 individuals had complete data on both exposure and outcome.

resultsNo statistically significant association was found between prenatal HEI and offspring's p-TMD status. Offspring of mothers with higher HEI scores were significantly less likely to report one or fewer headaches per month in young adulthood (adjusted OR [aOR] = 0.84; 95% confidence interval [CI], 0.73-0.96, p = 0.006). Specific pre-natal dietary domains associated with reduced headache risk included red meat scores (aOR = 0.98; 95% CI, 0.97-0.99, p = 0.006) and saturated fatty acids (aOR = 0.92; 95% CI, 0.86-0.99, p = 0.039).

conclusionOffspring of mothers with higher HEI scores, that is, healthier dietary choices during pregnancy, had significantly lower odds of reporting headaches but not p-TMD in young adulthood. Lower maternal intake of saturated fatty acids and red meat were associated with decreased odds of reporting headaches later in life.

Indexed as

Diet, HealthyHeadachePrenatal Exposure Delayed EffectsPrenatal Nutritional Physiological PhenomenaTemporomandibular Joint DisordersAdolescentAdultDenmarkFemaleHumansLongitudinal StudiesMalePregnancyProspective StudiesRisk FactorsYoung Adultcohort studiesdietary qualityheadachetemporomandibular disorders

Identifiers

PMID40831202
PMCPMC12849538

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.