Evidence map›Paper›PMID 40831171›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2025

[Effects of hyperoxia on the expression of hippocampal N-methyl D-aspartate receptor 1 and its synapse-associated molecules in neonatal rats].

Yi Xiong, Lin Cheng, Na Jiang, Tuan-Mei Wang, Tao Bo

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi XiongDepartment of Pediatrics, Third Xiangya Hosptial, Central South University, Changsha 410013, China.
Lin ChengDepartment of Pediatrics, Third Xiangya Hosptial, Central South University, Changsha 410013, China.
Na JiangChangsha Maternal and Child Healthcare Hospital, Changsha 410007, China.
Tuan-Mei WangChangsha Maternal and Child Healthcare Hospital, Changsha 410007, China.
Tao BoDepartment of Pediatrics, Third Xiangya Hosptial, Central South University, Changsha 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effects of hyperoxia on the expression of N-methyl-D-aspartate receptor 1 (NMDAR1) and its synapse-associated molecules, including cannabinoid receptor 1 (CB1R), postsynaptic density 95 (PSD95), and synapsin (SYN), in the hippocampus of neonatal rats.

methodsOne-day-old Sprague-Dawley neonatal rats were randomly divided into a hyperoxia group and a control group (

resultsAfter 7 days of hyperoxia exposure, the hyperoxia group showed decreased neuronal density and disordered arrangement in brain tissue. Compared with the control group, after 1 day of hyperoxia exposure, CB1R mRNA and both NMDAR1 and CB1R protein expression in the hyperoxia group were significantly downregulated, while SYN protein expression was significantly upregulated (

conclusionsContinuous hyperoxia exposure induces time-dependent changes in the expression levels of NMDAR1 and its synapse-associated molecules in the hippocampus of neonatal rats.

Indexed as

HippocampusHyperoxiaReceptors, N-Methyl-D-AspartateSynapsesAnimalsAnimals, NewbornDisks Large Homolog 4 ProteinFemaleMaleRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1RNA, MessengerSynapsinsDisks Large Homolog 4 ProteinDlg4 protein, ratReceptor, Cannabinoid, CB1Receptors, N-Methyl-D-AspartateRNA, MessengerSynapsinsBrain developmentHippocampusHyperoxiaNeonatal ratNMDA receptor 1

Identifiers

PMID40831171
PMCPMC12369529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.