Evidence map›Paper›PMID 40831164›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2025

[Clinical features and immunotherapy for children with loss-of-function/gain-of-function mutations in the

Hong-Wei Li, Yan-Hong Wang, Shang-Zhi Wu, Bi-Yun Zhang, Shi-Hui Xu, Jia-Xing Xu, Zhan-Hang Huang, Cheng-Yu Lu, De-Hui Chen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong-Wei LiDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Yan-Hong WangDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Shang-Zhi WuDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Bi-Yun ZhangDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Shi-Hui XuDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Jia-Xing XuDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Zhan-Hang HuangDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Cheng-Yu LuDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
De-Hui ChenDepartment of Pediatrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the clinical features of children with

methodsA retrospective analysis was performed for the clinical data of 10 children with

resultsFor the 10 children, the main clinical manifestations were recurrent rash since birth (7/10), cough (8/10), wheezing (5/10), expectoration (4/10), and purulent nasal discharge (4/10). Genotyping results showed that there was one child with heterozygous loss-of-function (LOF) mutation in the

conclusions

Indexed as

Gain of Function MutationImmunotherapyLoss of Function MutationSTAT Transcription FactorsChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesSTAT Transcription FactorsChildGain-of-function mutationImmunotherapyLoss-of-function mutationSTAT gene

Identifiers

PMID40831164
PMCPMC12369526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.