Trial reportMicrocirculation (New York, N.Y. : 1994)2025
Coronary Microvascular Dysfunction Alters the Pulsatile Behavior of the Resting Coronary Blood Flow.
Trial report in Microcirculation (New York, N.Y. : 1994), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328820 (DEFINE-FLOW), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
DEFINE-FLOW (Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect - Combined Pressure and Doppler FLOW Velocity Measurements)
Who cites it
3 citing papers in PubMed.
- Coronary Microvascular Dysfunction Alters the Pulsatile Behavior of the Resting Coronary Blood Flow.Microcirculation (New York, N.Y. : 1994) · 2025Trial
- Early diastolic dysfunction in patients with ischemia and no obstructive coronary artery disease: a prospective study on hybrid positron emission tomography-magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Negative expansion resistance (NER) phenomenon predicts hemodynamically non-significant coronary lesions.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVariations in resting pulsatile coronary flow velocity acceleration/deceleration characteristics (dU/dt) with respect to epicardial lesions and coronary microvascular dysfunction (CMD) remain incompletely understood.
methodThe coronary dU/dt pattern was extracted from the first derivative of the intracoronary Doppler velocity signal. Univariable and multivariable models evaluated the relationships between the dU/dt amplitudes, epicardial disease as well as CMD, defined by a blunted coronary flow reserve (CFR) adjusted for the concomitant epicardial disease severity (fractional flow reserve, FFR) yielding the microvascular resistance reserve (MRR). Functional CMD was defined by a blunted MRR (≤ 3.0) but normal hyperemic microvascular resistance (hMR < 2.5) whereas structural CMD was defined by a blunted MRR (≤ 3.0) combined with increased hMR (≥ 2.5). Six major acceleration or deceleration peaks were identified in each cardiac cycle; these were a (amplitude of peak diastolic acceleration), b (amplitude of early diastolic deceleration nadir), c (amplitude of peak diastolic re-acceleration), j (amplitude of end-diastolic deceleration nadir), x (amplitude of peak systolic acceleration), and z (amplitude of end-systolic deceleration nadir) waves.
resultsFunctional CMD was associated with amplification of a (β = 55.944, 95% CI [21.112, 90.777], p = 0.002) and × (β = 44.069, 95% CI [20.182, 67.955], p < 0.001), b (β = -34.019, 95% CI [-50.865, -17.173], p < 0.001), j (β = -48.723, 95% CI [-71.272, -26.174], p < 0.001), and z (β = -31.047, 95% CI [-53.596, -8.498], p = 0.007) waves. Structural CMD was associated with blunted a (β = -76.938, 95% CI [-113.125, -40.751], p < 0.001) and j (β = 24.787, 95% CI [1.361, 48.213], p = 0.039).
conclusionEpicardial disease severity is minimally associated with alterations in the resting dU/dt pattern, whereas CMD endotypes are associated with distinctively altered intrabeat pulsatility characteristics. Stronger acceleration magnitudes at rest do not indicate a healthier microcirculation or absence of CMD.
trial registrationClinicalTrials.gov (NCT02328820).
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