Evidence map›Paper›PMID 40830895›Full record

ArticleGenome biology2025

A message passing framework for precise cell state identification with scClassify2.

Wenze Ding, Yue Cao, Xiaohang Fu, Marni Torkel, Jean Yee Hwa Yang

Abstract read
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenze Ding *School of Mathematics and Statistics, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0003-0940-2885
Yue Cao *School of Mathematics and Statistics, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-2356-4031
Xiaohang FuSchool of Mathematics and Statistics, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0003-2101-1326
Marni TorkelSchool of Mathematics and Statistics, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.
Jean Yee Hwa YangSchool of Mathematics and Statistics, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia. jean.yang@sydney.edu.au.ORCID http://orcid.org/0000-0002-5271-2603

Funding

NHMRC Investigator APP2017023the Chan Zuckerberg Initiative Single Cell Biology Data Insights grant DI2-0000000197
6 · The paper itself

Abstract

Cell annotation is crucial for downstream exploration. Although many approaches, spanning from classic statistics to large language models, have been developed, most of their focus is on distinct cell types and overlook sequential cell populations. Here, we propose an annotation method, scClassify2, to specifically focus on adjacent cell state identification. By incorporating prior biological knowledge through a novel dual-layer architecture and ordinal regression, scClassify2 achieves competitive performance compared to other state-of-the-art methods. Besides single-cell RNA-sequencing data, scClassify2 is generalizable from different platforms including subcellular spatial transcriptomics data. We also develop a web server for academic uses.

Indexed as

Single-Cell AnalysisSoftwareHumansSequence Analysis, RNACell state identificationDual layer architectureMPNNOrdinal regressionScRNA-seq

Identifiers

PMID40830895
PMCPMC12362893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.