Trial reportBMC surgery2025
The effect of preoperative oral carbohydrate administration on postoperative glucometabolic response, subjective well being and quality of life in patients undergoing colorectal surgery: a randomized controlled double-blind study.
Trial report in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05402592 (The Effect of Preoperative Oral Carbohydrate Administration on Postoperative Glucometabolic Response, Subjective Well-being and Quality of Life in Patients Undergoing Colorectal Surgery), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Preoperative Oral Carbohydrate Administration on Postoperative Glucometabolic Response, Subjective Well-being and Quality of Life in Patients Undergoing Colorectal Surgery: A Randomized Prospective Trial
Who cites it
5 citing papers in PubMed.
- The Effect of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Adult Patients Undergoing On-Pump Cardiac Surgery: A Randomized Controlled Trial.Annals of cardiac anaesthesia · 2026Trial
- Fiftieth Anniversary of the Publication of the World Journal of Surgery Title: Landmark Advances in Colorectal Surgery: A Primer of a Fifty-Year Evolution.World journal of surgery · 2026Review
- Perioperative Interventions Based on Fasting Protocols and Carbohydrate Loading in Non-Cardiac Surgery in Older Adults: A Scoping Review.Medicina (Kaunas, Lithuania) · 2026Article
- Risk factors for postoperative gastrointestinal dysfunction in adult patients undergoing short laparoscopic surgery: a prospective exploratory observational study.BMC anesthesiology · 2026Observational
- The Influence of Preoperative Oral Carbohydrate Administration on the Perioperative Period in Children and Adolescents After Orthopedic Procedures-A Pilot Study.Healthcare (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlonged preoperative fasting may increase anxiety, insulin resistance, and surgical stress, whereas preoperative carbohydrate loading has been shown to improve metabolic response, reduce complications, and enhance recovery, as supported by ERAS protocols.
objectivesThis study aimed to examine the effects of preoperative oral carbohydrate ingestion on postoperative glucometabolic response, subjective well-being, quality of life, and surgical clinical outcomes in patients undergoing colorectal surgery.
methodsA prospective, randomized controlled double-blind study was conducted in a hospital in the Aegean region of Türkiye, including 50 patients scheduled for elective colorectal surgery. Data were collected using a structured form that included sociodemographic information, perioperative laboratory values, subjective well-being indicators, and the SF-36 Quality of Life Scale. The intervention group received 800 mL of a carbohydrate drink until midnight and 400 mL two hours before surgery; the control group received the same volumes of water. Participants, outcome assessors, and statistical analysts were blinded to group assignments. The researcher who administered the drinks was aware of group allocation but was not involved in outcome evaluation or data analysis.
resultsThe intervention group had shorter time to first flatulence (40.60 ± 4.52 vs 46.00 ± 4.22 h, p < 0.001), earlier defecation (68.64 ± 7.94 vs 81.84 ± 8.97 h, p < 0.001), earlier oral feeding (43.80 ± 4.84 vs 48.44 ± 3.87 h, p < 0.001), and shorter hospital stay (10.64 ± 1.52 vs 14.32 ± 3.69 days, p < 0.001) compared to the control group. Postoperative albumin levels were significantly higher and CRP levels significantly lower in the intervention group at 24 h. The SF-36 physical functioning score was significantly higher in the intervention group compared to the control group (82.00 ± 11.81 vs 61.40 ± 16.17, p < 0.001). No significant differences were found in insulin resistance (HOMA-IR), gastric volume, or pH between groups.
conclusionPreoperative oral carbohydrate intake was associated with improved clinical recovery indicators and quality of life outcomes. In particular, it contributed to earlier return of bowel function, reduced postoperative discomfort, and significantly shorter hospital stay, indicating enhanced postoperative recovery in patients undergoing colorectal surgery.
trial registrationFirst registered on 30.05.2022, NCT05402592 by ClinicalTrials.gov.
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