ArticleBMC gastroenterology2025
Association between gastrointestinal disorders and sleep-related problems: the mediating effect of depression.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications.World journal of clinical pediatrics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between gastrointestinal(GI) diseases and sleep-related problems—such as sleep trouble and sleep disorders—remains insufficiently understood.
methodsData were derived from the 2005–2014 U.S. National Health and Nutrition Examination Survey (NHANES). Multicollinearity was evaluated using variance inflation factors. Multivariable logistic regression and subgroup analyses were conducted to assess the association between GI diseases and sleep trouble. Mediation analyses explored whether depression mediated the relationships between GI diseases and sleep outcomes, including sleep trouble, sleep disorders, and sleep duration. Sensitivity analyses were performed to evaluate the robustness of the results.
resultsIn the context of fully adjusted models, individuals afflicted with gastrointestinal diseases exhibited an elevated propensity for experiencing sleep disturbances in comparison with those not affected by such conditions. (adjusted OR = 1.70, 95% CI: 1.41–2.05, P < .001). They also showed increased odds of sleep disorders (adjusted OR = 1.80, 95% CI: 1.34–2.41, P < .001) and a reduction in sleep duration (adjusted β = –0.15, 95% CI: –0.29 to –0.01, P = 0.038). These associations remained consistent across subgroups, including individuals without hypertension (adjusted OR = 1.69), without diabetes (adjusted OR = 1.72), with no smoking history (adjusted OR = 1.73), those with coronary artery disease (adjusted OR = 1.76), and those with higher DI-GM scores (adjusted OR = 1.81) (all P-values < .05). Mediation analysis indicated that depression partially mediated the associations between GI diseases and sleep trouble (Effect = 0.023, 95% CI: 0.022–0.035, P < .01), sleep disorders (Effect = 0.010, 95% CI: 0.008–0.014, P < .01), and sleep duration (Effect = –0.126, 95% CI: –0.248 to –0.050, P = 0.040). These mediation effects remained stable in sensitivity analyses.
conclusionsGI diseases are significantly associated with sleep disturbances, with depression serving as a partial mediator. These findings highlight the importance of addressing both gastrointestinal and psychological health in clinical efforts to improve sleep quality. Further research is needed to guide targeted interventions for this interconnected set of conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.