ArticleBMC public health2025
Development and validation of a decision tree model for prediction of insomnia risk among ischemic stroke convalescence patients.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Serum hypocretin, neurofilament heavy chain, and interleukin-1β as combined predictors of sleep disorders following acute ischemic stroke.Frontiers in neuroscience · 2026Article
- Targeting the microbiota-gut-brain axis in post-stroke insomnia: a phase-dependent therapeutic framework.Frontiers in neuroscience · 2026Review
- Predicting Post-Stroke Depression Risk in Elderly Patients Based on Machine Learning: A Retrospective Cohort Study Integrating Neuroimaging and Psychosocial Variables.Neuropsychiatric disease and treatment · 2026Article
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8 authors.
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Abstract
backgroundInsomnia is a common complication in ischemic stroke convalescence (ISC) patients. While the interaction of clinical, psychological, and social factors remains unclear, developing a predictive model system is urgently needed. Currently, few studies have established insomnia risk prediction models.
objectivesTo construct a decision tree model for insomnia risk among ISC patients based on the classification and regression tree algorithm.
designAcross-sectional study.
settingChina.
participantsThe study enrolled 823 adult ISC patients between February 2023 and October 2024. Participants were recruited from stroke units in two tertiary hospitals in Jilin Province.
methodsFollowing the TRIPOD+AI guidelines, we constructed a decision tree model utilizing data from the Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Social Support Scale (SSRS), and other assessment tools. Model validation encompassed 10-fold cross-validation, incorporating confusion matrix, ROC curves, calibration curve, and Brier scores. The model was trained on 623 patients and externally validated on an independent cohort of 200 cases.
resultsThe study revealed an insomnia prevalence of 37.72%camong ISC patients. Univariate analysis identified BMI, SAS, SSRS, FSS, SDS, and NIHSS as significant factors. The decision tree model delineated 24 pathways (depth = 6), with predictive contributions ranked as follows: SAS > SSRS > FSS > SDS > BMI > NIHSS, which were integrated into a nomogram. Internal validation exhibited robust predictive accuracy (90.4%), with a sensitivity of 0.96, specificity of 0.84, Youden index of 0.80, and F1 score of 0.89. The AUC was 0.96 (95% CI: 0.93-0.98; p < 0.001), indicating well-calibrated predictions (χ² = 9.36, p = 0.404). Brier scores were 0.06 for the training set and 0.08 for the validation set. External validation demonstrated an accuracy of 82%. The decision curve analysis demonstrated acceptable clinical utility.
conclusionThis model demonstrates promise in forecasting insomnia among ISC patients. Anxiety and social support emerged as the most influential predictors, with fatigue, depression, BMI, and stroke severity collectively offering a comprehensive outlook for anticipating post-stroke insomnia. These results have implications for informing future strategies in managing insomnia. The model's applicability is moderately robust, necessitating additional refinement to accurately pinpoint insomnia.
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