ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2025
Different Polymorphisms of the Renin-Angiotensin-Aldosterone System Genes are Associated with Poorer Blood Pressure Control in Hypertensive Older Adults.
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Subnational inequalities and spatially varying associations of elevated blood glucose among women in India: a national district-level biomarkers analysis.BMC public health · 2026Article
- Risk Factors Associated with Systemic Arterial Hypertension in Postmenopausal Women Engaged in Resistance Training: A Cross-Sectional Observational Study.International journal of environmental research and public health · 2026Observational
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Abstract
introductionAdequate blood pressure control (BPC) is crucial for preventing hypertension, as well as for mitigating the risks associated with inadequate control among hypertensive older adults. Identifying modifiable factors (i.e., dietary and biochemical patterns, sociodemographic characteristics, and health habits) and non-modifiable factors (i.e., genetic background) is crucial for improving control rates.
aimThis study aimed to analyze the association between Renin-Angiotensin-Aldosterone System gene polymorphisms, sociodemographic characteristics, health and lifestyle habits, and BPC in older adults.
methodsone hundred and forty-three older adults comprised the study population, and were genotyped for angiotensinogen (AGT) [M235T], renin (REN) [G2646A] angiotensin-converting enzyme (ACE) [InDel], angiotensin II type 1 receptor (AT1R) [A1166C] aldosterone synthase (CYP11B2) [C344T] gene polymorphisms. Sociodemographic characteristics, health, and lifestyle habits were recorded using questionnaires, and blood pressure was measured using standard methods. A Poisson multivariate regression was applied.
resultsOur finding indicated that, together, LDL-C, the A allele of the REN gene (G2646A), and genotype II of the ACE gene (InDel) were significantly associated with inadequate BPC in the community-dwelling older adults.
conclusionsDue to its non-modifiable nature, the genetic background has the potential to identify individuals with a greater risk of illness. The knowledge of the genetic profiles prone to impaired BPC and its interaction with modifiable factors could guide more effective behaviors and/or treatments aiming to mitigate the morbidity and mortality related to poor BPC among hypertensive older adults.
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