Evidence map›Paper›PMID 40830625›Full record

ArticleScientific reports2025

Inflammatory markers guide early risk stratification and prognosis in elderly patients with acute myocardial infarction.

XiaoLong Lin, Qian Fan, QiuYu Li, XiaoWen Bo, SiYuan Chen, XiaoFan Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

XiaoLong LinCenter for Coronary Artery Disease, Beijing AnZhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China.
Qian FanCenter for Coronary Artery Disease, Beijing AnZhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China.
QiuYu LiCenter for Coronary Artery Disease, Beijing AnZhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China.
XiaoWen BoCenter for Coronary Artery Disease, Beijing AnZhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China.
SiYuan ChenCenter for Coronary Artery Disease, Beijing AnZhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China.
XiaoFan WuCenter for Coronary Artery Disease, Beijing AnZhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China. drwuxf@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-sensitivity C-reactive protein (hs-CRP) has been associated with prognosis in acute myocardial infarction (AMI) patients, but data on its role in elderly individuals remains limited. This single-center, retrospective study included 590 elderly AMI patients, who were stratified into three groups based on hs-CRP tertiles. The incidence of adverse in-hospital events increased progressively across higher hs-CRP tertiles (17.2%, 25.5%, and 48%, P<0.001). Notably, patients who experienced these events had significantly higher hs-CRP levels compared to those without adverse outcomes (7.04 [2.38, 20.00] vs. 2.59 [1.06, 6.07], P<0.001). Multivariate logistic regression identified hs-CRP as an independent predictor of in-hospital outcomes in elderly AMI patients (Q3: OR 2.21, 95% CI 1.23-3.97, P=0.008). The area under the curve (AUC) for hs-CRP's predictive accuracy was 0.712 (95% CI 0.664-0.755, P<0.001). Furthermore, integrating hs-CRP into an established risk factor model significantly improved both reclassification and discrimination (Continuous NRI: 0.461, 95% CI 0.292-0.631, P<0.001; IDI: 0.046, 95% CI 0.025-0.067, P<0.001), although it did not substantially enhance the C-statistic (0.867 (95% CI 0.831-0.895, P<0.001) vs. 0.876 (95% CI 0.841-0.905, P<0.001) , P=0.183). These findings suggest that hs-CRP is a reliable and practical biomarker for predicting poor prognosis in elderly patients with AMI.

Indexed as

BiomarkersC-Reactive ProteinInflammationMyocardial InfarctionAgedAged, 80 and overFemaleHumansMalePrognosisRetrospective StudiesRisk AssessmentRisk FactorsBiomarkersC-Reactive ProteinAcute myocardial infarctionElderly patientsHigh sensitivity C-reactive proteinIn hospital outcomes

Identifiers

PMID40830625
PMCPMC12365152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.