Evidence map›Paper›PMID 40830621›Full record

ArticleScientific reports2025

Role of CD133 antibody-conjugated nanocarrier in enhancing the targetability of hepatocellular carcinoma stem cells.

Hadeer A Aglan, Ahmed A Abd-Rabou, Hanaa H Ahmed, Ghada H Elsayed, Mohamed S Kishta, Manar A Elhinnawi, Nadia S Mahmoud

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hadeer A AglanHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt. ha_dero@yahoo.com.ORCID http://orcid.org/0000-0003-0837-0172
Ahmed A Abd-RabouHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt. ahmedchemia87@yahoo.com.ORCID http://orcid.org/0000-0002-9875-7591
Hanaa H AhmedHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.ORCID http://orcid.org/0000-0001-8642-9251
Ghada H ElsayedHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.ORCID http://orcid.org/0000-0002-5505-217X
Mohamed S KishtaHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.ORCID http://orcid.org/0000-0002-2314-8820
Manar A ElhinnawiHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.ORCID http://orcid.org/0000-0002-0061-9060
Nadia S MahmoudHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.ORCID http://orcid.org/0000-0002-9085-4063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed at targeting hepatic cancer stem cells (CSCs) with quercetin (Q) or kaempferol (K) loaded into poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) decorated with CD133 antibody. For this purpose, the formulated Q NPs and K NPs and their free forms were evaluated for their cytotoxic potential, apoptotic activity, and anti-migratory effect against CD133

Indexed as

AC133 AntigenCarcinoma, HepatocellularLiver NeoplasmsNanoparticlesNeoplastic Stem CellsApoptosisCell Line, TumorCell MovementDrug CarriersHumansKaempferolsPolylactic Acid-Polyglycolic Acid CopolymerQuercetinAC133 AntigenDrug CarriersKaempferolsPolylactic Acid-Polyglycolic Acid CopolymerPROM1 protein, humanQuercetinCD133Hepatic cancer stem cellsKaempferolPLGA nanoparticlesQuercetin

Identifiers

PMID40830621
PMCPMC12365257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.