Evidence map›Paper›PMID 40830592›Full record

ArticleMolecular systems biology2025

Systems approach identifies monocyte imbalance in symptomatic and asymptomatic P. vivax malaria.

Stephanie I Studniberg, Mariam Bafit, Lisa J Ioannidis, Matthew J Worley, Leily Trianty, Retno A S Utami, Agatha M Puspitasari, Dwi Apriyanti, Farah N Coutrier, Jeanne R Poespoprodjo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular systems biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stephanie I StudnibergMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC, Australia.ORCID http://orcid.org/0000-0002-9452-4977
Mariam BafitMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC, Australia.
Lisa J IoannidisWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Matthew J WorleyMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC, Australia.
Leily TriantyEijkman Research Centre for Molecular Biology, East Java, Indonesia.
Retno A S UtamiExeins Health Initiative, Jakarta, Indonesia.
Agatha M PuspitasariExeins Health Initiative, Jakarta, Indonesia.
Dwi ApriyantiEijkman Research Centre for Molecular Biology, East Java, Indonesia.
Farah N CoutrierEijkman Research Centre for Molecular Biology, East Java, Indonesia.
Jeanne R PoespoprodjoTimika Malaria Research Program, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia.ORCID http://orcid.org/0000-0003-1573-734X
Enny KenangalemTimika Malaria Research Program, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia.
Benediktus AndriesTimika Malaria Research Program, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia.ORCID http://orcid.org/0000-0002-0354-456X
Pak PrayogaTimika Malaria Research Program, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia.
Ric N PriceGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.ORCID http://orcid.org/0000-0003-2000-2874
Rintis NoviyantiEijkman Research Centre for Molecular Biology, East Java, Indonesia.
Alexandra L GarnhamWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Diana S HansenMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC, Australia. diana.hansen@monash.edu.ORCID http://orcid.org/0000-0003-4511-7918

Funding

Australian Academy of Science (Australia, Australian Academy of Science) Regional Collaboration GrantFederal Government | DHAC | National Health and Medical Research Council (NHMRC) 2026175Federal Government | DHAC | National Health and Medical Research Council (NHMRC) 2028898Federal Government | DHAC | National Health and Medical Research Council (NHMRC) GNT1132975
6 · The paper itself

Abstract

Although asymptomatic malaria was historically perceived as innocuous, emerging evidence revealed an immunosuppressive signature induced by asymptomatic Plasmodium falciparum infections. To examine if a similar process occurs in Plasmodium vivax malaria, we pursued a systems approach, integrating transcriptional profiling together with previously reported and novel mass cytometry phenotypes from individuals with symptomatic and asymptomatic P. vivax malaria. Symptomatic P. vivax malaria featured upregulation of anti-inflammatory pathways and checkpoint receptors. A profound downregulation of transcripts with roles in monocyte function was observed in symptomatic P. vivax malaria. This reduction in monocyte transcriptional activity was accompanied by a significant depletion of CCR2

Indexed as

Malaria, VivaxMonocytesPlasmodium vivaxSystems BiologyAdultAsymptomatic InfectionsFemaleGene Expression ProfilingGene Expression RegulationHumansMaleAsymptomatic MalariaMonocytesPlasmodium vivaxSystems ImmunologyTranscriptional Profiling

Identifiers

PMID40830592
PMCPMC12583509

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.