SynthesisClinical neuroradiology2025
Efficacy and Safety of Mechanical Thrombectomy for Patients with Infective Endocarditis-Related Large Vessel Occlusion: a Systematic Review and Meta-Analysis.
Synthesis in Clinical neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute ischemic stroke (AIS) is the most common neurological complication of infective endocarditis (IE), occurring in 20-40% of patients. In this context, while mechanical thrombectomy (MT) is the standard treatment for patients with AIS due to large-vessel occlusion (LVO), its efficacy and safety in patients with stroke secondary to IE remain unclear.
objectiveTherefore, a more robust analysis of the efficacy and safety of MT in patients with AIS due to IE was conducted to address the gaps identified in previous studies.
methodsAn extensive search of PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus databases was conducted from inception to December 2024. The endpoints of interest were: (1) favorable functional outcomes at 90 days, (2) successful recanalization, (3) symptomatic intracranial hemorrhage (sICH), (4) any intracranial hemorrhage (aICH), and (5) overall mortality. The pooled proportion rates were employed with a random effects model with 95% Confidence Intervals (CI) and risk ratios (RR) for binary outcomes with 95% CI. I
resultsEight studies published between 2017 and 2024 enrolled 2037 patients (mean age 57.9 years, 62.3% women), of whom 1401 (69%) received mechanical or endovascular thrombectomy for Infective Endocarditis-Related Large Vessel Occlusion (IE-LVO) stroke. A pooled proportion of 29.0% for favorable functional outcomes (mRS 0-2) was reported (95% CI 14.0-43.0%; I
conclusionHigh successful recanalization rates were achieved in this population through MT, demonstrating its potential as an effective treatment for IE-LVO. However, the clinical outcomes of patients with IE-LVO were significantly unfavorable compared with those of patients without IE-LVO.
Indexed as
Identifiers
40830541What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.