SynthesisEuropean journal of medical research2025
Food-derived extracellular vesicles for treatment of osteoporosis: a systematic review and meta-analysis of preclinical animal studies.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coumarins in musculoskeletal health: a systematic review.Frontiers in nutrition · 2026Pooled it
- Milk-derived extracellular vesicles: nutritional significance, nano-delivery potential, and emerging therapeutic applications - an updated review.Food science of animal resources · 2026Review
- miR-1290 serves as a potential biomarker for osteoporotic fracture and regulates osteoblast function by targeting KDM5A.Journal of orthopaedic surgery and research · 2026Article
- Non-Bone-Derived Extracellular Vesicles in Osteoporosis: Evidence Mapping and Nanomedicine Translation.International journal of nanomedicine · 2026Review
- A bibliometric analysis of the current state and future directions of osteoporosis pharmacological treatment.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFood-derived extracellular vesicles (EVs) are considered a novel therapeutic approach for osteoporosis. However, their efficacy in treating osteoporosis remains unclear. This systematic review and meta-analysis aim to preliminarily evaluate and explore the effects of food-derived EVs in animal models of osteoporosis.
methodsPubMed, Embase, and Web of Science databases were searched for preclinical studies on food-derived EVs in the treatment of osteoporosis, up to November 25, 2024. A meta-analysis was conducted to evaluate the effects of food-derived EVs on bone mineral density (BMD), bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation/marrow thickness (Tb.Sp), trabecular number (Tb.N), and serum bone turnover markers in osteoporosis animal models.
resultsSix studies met the inclusion criteria for the meta-analysis. The results showed that food-derived EVs contributed to increases in BMD and bone mass markers (BV/TV, Tb.Th, and Tb.N), while promoting the expression of bone formation markers (OPG and PINP) and reducing the expression of bone resorption markers (TRACP 5b and β-CTX). Sensitivity analysis demonstrated the stability of the pooled effect sizes.
conclusionsThe present meta-analysis suggested that food-derived EVs could improve BMD and bone mass in animal models of osteoporosis. This positive effect may be attributed to the promotion of bone formation mediated by the upregulation of osteogenic markers and the inhibition of bone resorption mediated by the downregulation of osteoclastic markers. Moreover, it is necessary to conduct studies with larger sample sizes and using other animal models to provide important insights for clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.