ReviewBiomarker research2025
The distinct landscape of tumor immune microenvironment in homologous recombination deficient cancers.
Review in Biomarker research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Prognostic significance of DNA damage response-related markers in esophageal squamous cell carcinoma using machine learning approaches.Journal of gastrointestinal oncology · 2026Article
- Review
- Integrative transcriptomic profiling of tumor patients in surgical ICU: identifying prognostic immune signatures.Frontiers in molecular biosciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Homologous recombination deficiency (HRD) is a common characteristic of human cancers, which occurs most frequently in ovarian and breast cancers. The unique genetic vulnerabilities, coupled with the synthetic lethality effect of Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPi), provide a promising opportunity for targeting HRD cancers. However, only a few HRD patients benefit from PARPi monotherapy, and it is therefore imperative to explore effective combination therapies for HRD tumors. Growing evidence has underscored the distinct tumor microenvironment (TME) landscape of HRD cancers. Immune activation and immune suppression co-exist in a dynamic balance during the development of HRD cancers. At the late stage, however, negative immune regulation predominates, resulting in the formation of an immunosuppressive microenvironment. This intricate network reprograms cancer biology in multiple aspects and serves as a potential target for cancer treatment. In this review, we briefly outline the current HRD tests and genetic characteristics of HRD cancers, focusing on breast, ovarian, pancreatic, and prostate cancers. We then summarize the interactions and crosstalk between immune cells and cancer cells, as well as various signaling pathways within the TME of HRD cancers. Additionally, we highlight recent advances in combining PARP inhibitors with immunotherapies in preclinical models and clinical trials of HRD cancers. This review provides valuable insights and perspectives into the distinct landscape of TME in HRD cancers, and offers a rationale for expanding the application of this combined therapeutic approach to a broader range of HRD cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.