Evidence map›Paper›PMID 40830525›Full record

ArticleInfectious diseases of poverty2025

Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages.

Xiao-Nan Zheng, Hong-Yu Song, Hany M Elsheikha, Chen-Ran Tian, Xing Tian, Qing Liu, Wen-Bin Zheng, Xing-Quan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious diseases of poverty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Apicomplexan parasites in urban corvids: Presence ofCurrent research in parasitology & vector-borne diseases · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao-Nan ZhengLaboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, People's Republic of China. zhengxiaonan8889@126.com.
Hong-Yu SongLaboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, People's Republic of China.
Hany M ElsheikhaFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.
Chen-Ran TianLaboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, People's Republic of China.
Xing TianLaboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, People's Republic of China.
Qing LiuLaboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, People's Republic of China.
Wen-Bin ZhengLaboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, People's Republic of China.
Xing-Quan ZhuLaboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, People's Republic of China. xingquanzhu1@hotmail.com.ORCID http://orcid.org/0000-0003-2530-4628

Funding

National Key Research and Development Program of China 2021YFC2300800National Key Research and Development Program of China 2021YFC2300802the National Natural Science Foundation of China 32402912the Shanxi Provincial Basic Research Program 202403021212085the Special Research Fund of Shanxi Agricultural University for High-level Talents 2021XG001
6 · The paper itself

Abstract

backgroundToxoplasma gondii is a globally widespread zoonotic parasite, infecting nearly one-third of the human population, often leading to chronic, latent infections. Among the emerging layers of gene regulation, 5-methylcytosine (m

methodsThe comparative m

resultsOur analysis revealed a total of 5129, 4968, and 4577 m

conclusionsThis study presents the first m

Indexed as

5-MethylcytosineEpigenomeToxoplasmaAnimalsDNA MethylationHumans5-Methylcytosine5-methylcytosineEpitranscriptomic regulationMethylated RNA immunoprecipitation sequencingRNA sequencingToxoplasma gondiiToxoplasmosis

Identifiers

PMID40830525
PMCPMC12362873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.