Evidence map›Paper›PMID 40830453›Full record

ArticleBMC musculoskeletal disorders2025

A case report of dermatofibrosarcoma protuberans with osteolytic.

Zuyao Song, Weiyi Gong, Hongyan Zhang, Yuqiang Wang, Wenfei Wang, Xiaokun Hu

Abstract readCase Reports
In one paragraph

Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Zuyao SongShengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying City, Shandong Province, China.
Weiyi GongShengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying City, Shandong Province, China.
Hongyan ZhangShengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying City, Shandong Province, China.
Yuqiang WangShengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying City, Shandong Province, China.
Wenfei WangShengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying City, Shandong Province, China. wangwenfei2012y@126.com.
Xiaokun HuAffiliated Hospital of Qingdao University, No. 1677, Wutai Mountain Road, Huangdao District, Qingdao City, Shandong Province, China. huxiaokun770@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDermatofibrosarcoma protuberans (DFSP) is a rare, low-to-intermediate grade malignant soft tissue sarcoma that is prone to local recurrence after surgery but rarely metastasizes to distant sites. However, in this case, the tumor metastasized to the humerus and presented as a solitary lesion. CASE PRESENTATION: A 42-year-old male patient presented with pain and limited mobility in the left upper limb, with a history of surgery for DFSP in the popliteal fossa. Imaging examinations revealed bone destruction in the proximal humerus and a soft tissue mass, with the lesion measuring 11.0 × 8.5 × 7.0 cm. Aspiration biopsy confirmed that the lesion in the humerus was a metastatic tumor. After two months of palliative treatment, follow-up examinations showed a reduction in the size of the lesion.Seven months after the treatment, the humeral lesion had progressed, and multiple new bone metastases were found.

conclusionsMetastasis of DFSP is rare, and bone metastasis is even rarer. We need to integrate medical history, perform comprehensive diagnosis through immunohistochemistry, molecular pathology monitoring, and imaging examinations. Additionally, this case reminds us that when encountering patients who primarily complain of bone pain during the initial diagnosis, we should thoroughly inquire about their medical and surgical history, conduct a comprehensive analysis, and make an integrated judgment. When necessary, perform a core biopsy first to determine the origin of the lesion. This approach allows us to provide patients with as comprehensive a range of treatment options as possible, thereby improving their quality of life.

Indexed as

Bone NeoplasmsDermatofibrosarcomaHumerusOsteolysisSkin NeoplasmsAdultHumansMaleBone metastasisCTDermatofibrosarcoma protuberansMRI

Identifiers

PMID40830453
PMCPMC12363061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.