ArticleBMC pediatrics2025
Respiratory infection induced episode of alveolar hemorrhage (RIIEAH) in the pediatric diffuse alveolar hemorrhage: a retrospective single-center study.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Diffuse Alveolar Hemorrhage Complicating Influenza A Infection in an Immunocompetent Infant: A Case Report with Focused Pediatric Review.Journal of clinical medicine · 2026Article
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7 authors.
Funding
Abstract
backgroundRespiratory infections are recognized as common triggers of alveolar hemorrhage episodes in pediatric diffuse alveolar hemorrhage (DAH). However, comprehensive studies investigating this association in detail remain limited. The aim of this study was to explore the etiological spectrum, clinical features, treatment strategies and outcomes of the respiratory infection induced episode of alveolar hemorrhage (RIIEAH) in the pediatric DAH.
methodsThe children of DAH who had RIIEAH and a definite etiological diagnosis were included. All the subjects had been hospitalized in the Department of Pediatrics at the First Affiliated Hospital of Guangxi Medical University from January 2023 to February 2024. A retrospective, single-center study was conducted.
results1. A total of 21 RIIEAHs were included, in which 12 RIIEAHs occurred at the unstable stage, 6 RIIEAHs occurred at the stable stage and 3 RIIEAHs occurred at the end stage. 2. Various pathogens could result in RIIEAHs including mycoplasma pneumoniae (n = 7), coronavirus (n = 3), haemophilus influenzae (n = 3), chlamydia pneumoniae (n = 2), human metapneumovirus (n = 2), acinetobacter baumannii (n = 1), pueumocystis carinii (n = 1) and mixed pathogens (n = 2). 3. The majority of the RIIEAHs (n = 19) presented with prodromal symptoms. Clinical manifestations of RIIEAHs included worsening anemia (n = 13), hemoptysis (n = 13), bleeding on bronchoscopy (n = 12) and dyspnea (n = 9). 4. An intensive glucocorticoid therapy was administrated in the 19 RIIEAHs, in which 18 RIIEAHs resolved.
conclusionsRIIEAH can be caused by various pathogens at any disease stage of pediatric DAH and an intensive glucocorticoid therapy seems to be effective for this condition.
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