Evidence map›Paper›PMID 40830437›Full record

ArticleBMC pregnancy and childbirth2025

Association of early postnatal decline in fetal hemoglobin with bronchopulmonary dysplasia in very low birth weight infants: a cohort study.

Chunying Niu, Hui Wu, Zhang Lin, Xiangpan Li, Dan Dang, Xin Mu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Assessment of iron sufficiency in premature infants treated with darbepoetin using conventional and novel erythrocyte metrics.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunying NiuDepartment of Neonatology, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Hui WuDepartment of Neonatology, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Zhang LinDepartment of Neonatology, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Xiangpan LiDepartment of Neonatology, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Dan DangDepartment of Neonatology, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Xin MuDepartment of Neonatology, Children's Medical Center, The First Hospital of Jilin University, Changchun, China. muxin_jilin@jlu.edu.cn.

Funding

Beijing Medical and Health Foundation YWJKJJHKYJJ-KXETHX004Jilin Provincial Department of Science and Technology 20230204080YYNational Natural Science Foundation of China 82271737National Natural Science Foundation of China 82301952
6 · The paper itself

Abstract

purposeThis study aims to examine the relationship between early fetal hemoglobin (HbF) decline, as a marker of oxidative stress, and the risk of bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) infants, with a focus on identifying critical risk thresholds.

methodsA prospective cohort study was conducted on VLBW infants admitted to the First Hospital of Jilin University. HbF decline was assessed by measuring absolute reduction and rate of decline within the first 7 days of life. The primary outcomes were mortality and/or development of BPD.

resultsA total of 294 infants were included in the study, of whom 5 (1.70%) died, and 142 (48.3%) developed BPD. A nonlinear relationship between HbF decline in the first 7 days and the primary outcomes was observed. Thresholds of 3 g/L for absolute HbF decline and 0.05 for the rate of decline were identified using a two-piecewise linear regression model. Infants were classified into low and high HbF decline groups based on these thresholds. Multivariate logistic regression showed a significantly higher risk of BPD in the high HbF decline group (OR = 2.77, 95% CI 1.52-5.02, P < 0.001) Subgroup analyses largely confirmed these findings.

conclusionsA nonlinear correlation was identified between HbF decline in the first 7 days and the risk of mortality and/or BPD in VLBW infants. An absolute HbF decline > 3 g/L or a rate > 0.05 was significantly associated with increased risk, offering a basis for BPD risk prediction.

Indexed as

Bronchopulmonary DysplasiaFetal HemoglobinInfant, Very Low Birth WeightBiomarkersCohort StudiesFemaleHumansInfant, NewbornInfant, PrematureMaleOxidative StressProspective StudiesRisk FactorsBiomarkersFetal HemoglobinBronchopulmonary dysplasiaFetal hemoglobinSmooth curve fittingVery low birth weight infants

Identifiers

PMID40830437
PMCPMC12366162

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.