Evidence map›Paper›PMID 40830434›Full record

ArticleBMC microbiology2025

Prevalence and molecular basis of resistance to echinocandins among clinical Candida glabrata isolates in Guangdong province, China.

Weihong Lin, Yaqin Peng, Bo Xiang, Jingchun Fang, Junkai Ye, Penghao Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Alkylamidobetaines Induced Changes in Multidrug-Resistant, BiofilmingInternational journal of molecular sciences · 2026
    Article
  2. Recent Outbreaks, Resistance Trends, and Control Measures inJournal of fungi (Basel, Switzerland) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weihong LinDepartment of Clinical Laboratory, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, Guangdong, China.
Yaqin PengDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510120, Guangdong, China.
Bo XiangDepartment of Clinical Laboratory, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, Guangdong, China.
Jingchun FangDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510120, Guangdong, China.
Junkai YeDepartment of Clinical Laboratory, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, Guangdong, China.
Penghao GuoDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510120, Guangdong, China. jackgph@163.com.

Funding

Guangzhou Science and Technology Bureau Municipal School (Institute) Co-funded Project 202201020443
6 · The paper itself

Abstract

backgroundInfections caused by Candida glabrata have raised increasing concerns, particularly due to the increasing resistance to echinocandins.

objectivesThis study investigated echinocandins susceptibility trends in C. glabrata isolates and explored the mechanisms driving resistance.

methodsWe analyzed 418 strains of C. glabrata derived from hospitalized patients. Phenotypic resistance was assessed, and genotypic analysis was performed to identify mutations in the hotspot-1 and hotspot-2 regions of the FKS1 and FKS2 genes. Additionally, genotyping was conducted using multilocus sequence typing (MLST).

resultsThe resistance rates to caspofungin, anidulafungin, and micafungin were 5.0%, 3.8%, and 4.0%, respectively, while fluconazole resistance was observed in 9.6% of the strains. Notably, 1.0% of the strains demonstrated resistance to both fluconazole and echinocandins. Mutations in the FKS genes were identified in 11 strains, predominantly in the FKS2-HS1 region. The most prevalent mutation was the F659 deletion (54.54%, 6/11), followed by S663F (18.18%, 2/11). Other mutations, including F659S, F659Y, and S663P, were also detected. These 11 mutated strains were classified into six distinct sequence types (STs), with ST208 being the most prevalent.

conclusionThe resistance rate of C. glabrata to echinocandins has been increasing annually in Guangdong province. Echinocandin resistance is associated with mutations in the FKS2 gene.

Indexed as

Antifungal AgentsCandida glabrataCandidiasisDrug Resistance, FungalEchinocandinsChinaFemaleFungal ProteinsGenotypeHumansMaleMicrobial Sensitivity TestsMiddle AgedMultilocus Sequence TypingMutationPrevalenceAntifungal AgentsEchinocandinsFungal ProteinsCandida glabrataEchinocandin resistanceFungal drug resistance surveillanceMolecular epidemiology

Identifiers

PMID40830434
PMCPMC12366116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.