ArticleCommunications biology2025
A universal monoallelic human leukocyte antigen class II immunopeptidomic platform for defining the immunogenicity potential of therapeutic proteins.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Blind Spots in HLA Class II Detection Generate Challenges for Antibody and RNA-based Assays.Transplantation · 2026Article
- Review: application and opportunities for machine learning and artificial intelligence in preclinical immunogenicity risk assessment.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An essential criterion for understanding the immunogenicity potential of biotherapeutic proteins is defining the set of peptides processed and presented by human leukocyte antigen (HLA) class II molecules. The heterozygotic state of most individuals and the extreme polymorphic nature of these molecules preclude efforts to define both the precise sequences presented by various alleles and the percentage of patients that are subject to immune responses that can negate clinical benefit and/or result in adverse events. We have developed a diverse, robust, and reproducible monoallelic HLA-DRB1 system in professional antigen presenting cells capable of examining the immunogenic potential of any human IgG. Determination of the allelic restriction of adalimumab CD4 T cell epitopes for two distinct geographic populations underscores the vitality of this system as a central component of a preclinical immunogenicity risk assessment strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.