Evidence map›Paper›PMID 40830395›Full record

ArticleScientific reports2025

Sevoflurane inhibition of the developmentally expressed neuronal sodium channel Na

Jiaxin Xiang, Karl F Herold, Jimcy Platholi, Hugh C Hemmings

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiaxin Xiang *Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Karl F Herold *Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Jimcy PlatholiDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA. jip2003@med.cornell.edu.
Hugh C HemmingsDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA. hchemmi@med.cornell.edu.

Funding

SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTIONR01GM058055 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HEMMINGS, HUGH C · 1998 to 2023
$10.1M
Mechanisms of anesthetic-induced synaptic plasticityR01GM130722 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI PLATHOLI, JIMCY · 2019 to 2023
$1.8M
Hugh C. Hemmings Jr. R01 GM58055NIGMS NIH HHS R01 GM058055NIGMS NIH HHS R01 GM130722
6 · The paper itself

Abstract

Neuronal voltage-gated sodium channels (Na

Indexed as

Anesthetics, InhalationNAV1.3 Voltage-Gated Sodium ChannelNeuronsSevofluraneHEK293 CellsHumansAnesthetics, InhalationNAV1.3 Voltage-Gated Sodium ChannelSevofluraneAnesthetic mechanismPersistent currentRamp currentVolatile anestheticVoltage-gated sodium channel

Identifiers

PMID40830395
PMCPMC12365293

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.