Evidence map›Paper›PMID 40830381›Full record

ArticleScientific reports2025

Pharmacological activation of BK channels protects against LPS-induced pneumonia.

Tatiana Zyrianova, Benjamin Lopez, Janelle SooHoo, Christian Boehmer, Annie Ye, Hailey Kang, Nairrita Majumder, Andreas Schwingshackl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tatiana ZyrianovaDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA. tatiana.zyryanova@gmail.com.
Benjamin LopezDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Janelle SooHooDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Christian BoehmerDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Annie YeDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Hailey KangDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Nairrita MajumderDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Andreas SchwingshacklDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Funding

Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung InjuryR01HL146821 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHWINGSHACKL, ANDREAS · 2020 to 2024
$2.8M
American Heart Association 20TPA35490010 (A.S.)American Heart Association 23CDA1052265 (T.Z.)American Heart Association 25POST1366363 (N.M.)NHLBI NIH HHS R01 HL146821NIH HHS : R01HL146821-01 (A.S.)U.S. Department of Defense W81XWH2210040 (T.Z.)
6 · The paper itself

Abstract

Bacterial pneumonia causes 1.4 million deaths annually worldwide. Besides antibiotics, current treatments are mostly supportive, and no other targeted therapies exist that improve patient outcomes. Key features of bacterial pneumonia include alveolar inflammation, including inflammatory cell infiltration, mediator release, and alveolar-capillary barrier dysfunction. We previously demonstrated that plasma membrane hyperpolarization via large conductance K

Indexed as

Large-Conductance Calcium-Activated Potassium ChannelsLipopolysaccharidesPneumoniaPneumonia, BacterialAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalHumansHydrogen PeroxideMaleMiceMice, Inbred C57BLReactive Oxygen SpeciesHydrogen PeroxideLarge-Conductance Calcium-Activated Potassium ChannelsLipopolysaccharidesReactive Oxygen Species

Identifiers

PMID40830381
PMCPMC12365261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.