ArticleScientific reports2025
Association of new Life's Essential 8 with biological aging among the national health and nutrition examination surveys.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Accelerated Biological Aging, Neurodegenerative Disease, and Mortality in Cardiovascular Disease Patients: Mediation and Modification Analysis.CNS neuroscience & therapeutics · 2026Article
- Bidirectional associations between biological aging, cardiovascular health, and cardiovascular risk: findings from the INSPIRE-T lifespan cohort.GeroScience · 2026Article
- DNA methylation signatures of Life's Essential 8 and their implications for dementia.Alzheimer's research & therapy · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Life's Essential 8 (LE8) score was updated by the American Heart Association, which constituted cardiovascular health (CVH) and was significantly associated with overall and cardiovascular disease-specific mortality. The aim of this research was to evaluate the connection between LE8, the newly revised indicator of cardiovascular health, and the acceleration of biological age. Participants for this study were selected from the National Health and Nutrition Examination Survey. The LE8 scores, derived from measurements following the American Heart Association definitions, were categorized into three levels: low, moderate, and high, on a scale of 0 to 100. The PhenoAge algorithm was used to compute biological age, while the PhenoAge advancement was used to assess biological age acceleration. Linear and logistic regression analyses were used to examine the association between the LE8 score and biological age. A total of 17,153 individuals with an average age of 47.54 were included in the study. The average LE8 score was 68, and the average Phenotypic age was 44.61. Individuals with higher LE8 scores were found to have a younger Phenotypic age, as demonstrated by their lower PhenoAge scores. After controlling for potential confounding variables, a higher LE8 score was found to be associated with a decrease in PhenoAge advancement (β = - 1.22, P < 0.01) and a lower likelihood of biological aging (OR = 0.65, P < 0.01). Both health behavior and health factor scores were associated with biological aging (both P < 0.01). Each type of LE8 score in the high group was positively associated with biological aging (both P < 0.01). A significant inverse association between LE8 score and biological aging was observed in all subgroups (both P < 0.01). The LE8 and its subscale scores showed a negative association with the likelihood of phenotypic aging. Maintaining ideal CVH levels could be advantageous in avoiding the potential acceleration of biological aging.
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