Evidence map›Paper›PMID 40830367›Full record

Observational studyScientific reports2025

Three-dimensional analysis of intraepidermal nerve fibres and Langerhans cells in keloids with a focus on pruritus.

Haruka Matsuzoe, Koh-Ei Toyoshima, Miki Takase, Ayako Tsuchiya, Mika Ikeda, Motoko Naitoh, Kazuya Kataoka, Tomoya Kawabata, Miho Ogawa, Naoki Morimoto and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haruka MatsuzoeDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Koh-Ei ToyoshimaLaboratory for Organ Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, 650-0047, Japan.
Miki TakaseLaboratory for Organ Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, 650-0047, Japan.
Ayako TsuchiyaLaboratory for Organ Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, 650-0047, Japan.
Mika IkedaDepartment of Plastic and Reconstructive Surgery, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.
Motoko NaitohDepartment of Plastic and Reconstructive Surgery, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.
Kazuya KataokaDepartment of Plastic and Reconstructive Surgery, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.
Tomoya KawabataDepartment of Plastic and Reconstructive Surgery, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.
Miho OgawaLaboratory for Organ Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, 650-0047, Japan.
Naoki MorimotoDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Takashi TsujiLaboratory for Organ Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, 650-0047, Japan. takashi.tsuji@riken.jp.

Funding

Japan Society for the Promotion of Science 18K17010
6 · The paper itself

Abstract

Keloids are intractable dermato-fibrotic lesions that progressively expands from the primary lesion to the surrounding normal areas. In this study, we investigated uncontrollable pruritus in keloids and the association between keloid symptoms and pruritus using three-dimensional immunofluorescence for the analysis of nerve fibres and Langerhans cells in the anterior chest and ear keloids, and the analysis of messenger-RNA expression of substance P as a pruritus mediator. Nerve fibres infiltrating the epidermis were numerous in the periphery of the anterior chest keloids, where pruritus was reported, with some extending into the granular layer. However, there was no difference in Langerhans cells during pruritus, location or region of the keloid. Furthermore, we observed substance P gene expression in the periphery of the anterior chest keloids. Our observational study suggests an association between intractable pruritus in anterior keloid lesions, increased intraepidermal nerve fibre density, and elevated expression of Th2 cytokines and substance P.

Indexed as

EpidermisKeloidLangerhans CellsNerve FibersPruritusAdultFemaleHumansImaging, Three-DimensionalMaleMiddle AgedSubstance PYoung AdultSubstance PIntraepidermal nerve fibresKeloidsLangerhans cellsPruritus

Identifiers

PMID40830367
PMCPMC12365267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.