Evidence map›Paper›PMID 40830350›Full record

ArticleNature communications2025

Reverse polarity of amide nitrogen enables expedient access to N-cyano amides.

Heng Yang, Xiangke Zhang, Fei-Yang Cao, Yu-Heng Zhang, Yan Pan, Ye-Cheng Wang, Mingji Dai, Jian-Jun Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heng Yang *Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Xiangke Zhang *Department of Chemistry, University of California, Berkeley, Berkeley, California, USA.
Fei-Yang CaoDepartment of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Yu-Heng ZhangDepartment of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Yan PanDepartment of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Ye-Cheng WangDepartment of Chemistry, University of California, Berkeley, Berkeley, California, USA.ORCID http://orcid.org/0000-0003-2649-2683
Mingji DaiDepartment of Chemistry, Emory University, Atlanta, Georgia, USA. mingji.dai@emory.edu.ORCID http://orcid.org/0000-0001-7956-6426
Jian-Jun DaiDepartment of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China. daijj@hfut.edu.cn.ORCID http://orcid.org/0000-0001-7918-0080

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21871074Natural Science Foundation of Anhui Province (Anhui Provincial Natural Science Foundation) 2308085MB39
6 · The paper itself

Abstract

N-Cyano amides are pivotal in agrochemicals, biologically active compounds, and nitrogen-containing heterocycles synthesis. Here, we present an umpolung cyanation strategy for the synthesis of N-cyano amides. By applying the readily accessible O-tosyl hydroxamates as nitrogen electrophiles, direct nucleophilic cyanation can be achieved with trimethylsilyl cyanide (TMSCN) under mild and transition metal-free conditions. This protocol features excellent functional group tolerance, easy scalability, and broad substrate scope (over 70 examples). Moreover, preliminary experimental studies and density functional theory (DFT) calculations support an S

Identifiers

PMID40830350
PMCPMC12365010

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.