Evidence map›Paper›PMID 40830330›Full record

ArticleMolecular diversity2026

Discovery of indole-carbohydrazide hybrids as novel broad-spectrum fungicidal lead compound though membrane-targeting mechanism.

Ying Wu, Li-Hui Shao, Xian-Qun Hu, Yu Long, Yuan-Yuan Wu, Pei-Bu Yu, Ai-Ping Yan, Long-Fei Li, Xiang Zhou, Song Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying Wu *State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
Li-Hui Shao *State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
Xian-Qun HuState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
Yu LongState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
Yuan-Yuan WuState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
Pei-Bu YuState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
Ai-Ping YanState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
Long-Fei LiState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
Xiang ZhouState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China. zhoux1534@163.com.
Song YangState Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China. jhzx.msm@gmail.com.

Funding

National Key Research and Development Program of China 2022YFD1700300National Natural Science Foundation of China 32160661National Natural Science Foundation of China 32372610the Central Government Guides Local Science and Technology Development Fund Projects [Qiankehezhongyindi [2023]001]the National Key Research and Development Program of China No. 2024YFE0214300
6 · The paper itself

Abstract

The escalating prevalence of fungicide resistance has severely diminished the effectiveness of conventional antifungal agents, creating substantial challenges for fungal infection control. To combat this emerging threat, we rationally designed a series of indole-carbohydrazide hybrids, aiming to develop novel membrane-targeting antifungal agents. Of particular note, compound b6 demonstrated optimal antifungal efficacy against Colletotrichum fructicola (C. f., EC

Indexed as

Antifungal AgentsCell MembraneDrug DiscoveryFungicides, IndustrialHydrazinesIndolesAnimalsCell Membrane PermeabilityColletotrichumHumansMicrobial Sensitivity TestsZebrafishAntifungal AgentscarbohydrazideFungicides, IndustrialHydrazinesindoleIndolesAntifungal activityCarbohydrazideIndole derivativesMembrane-targeting agentsPhytopathogenic fungi

Identifiers

PMID40830330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.