Evidence map›Paper›PMID 40830168›Full record

Observational studyScientific reports2025

Childhood resolution of early abnormal miRNA following neonatal encephalopathy.

Johana M Isaza-Correa, Eman Isweisi, Ronan Murphy, Tim Hurley, Matthew McGovern, Moira O'Reilly, Sean Tamgumus, Graham King, Mary O'Dea, Lynne A Kelly and 6 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Johana M Isaza-CorreaDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Eman IsweisiDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Ronan MurphyDiscipline of Physiology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Tim HurleyDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Matthew McGovernDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Moira O'ReillyDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Sean TamgumusNeonatology, Children's Health Ireland at Crumlin & Tallaght, Dublin, Ireland.
Graham KingNational Maternity Hospital, Dublin, Ireland.
Mary O'DeaDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Lynne A KellyDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Mandy DalyIrish Neonatal Health Alliance (INHA), Dublin, Ireland.
Jan MiletinPaediatrics, Coombe Hospital, Dublin, Ireland.
Claudine VavasseurNational Maternity Hospital, Dublin, Ireland.
John KelleherPaediatrics, Coombe Hospital, Dublin, Ireland.
Eva M Jimenez-MateosDiscipline of Physiology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Eleanor J MolloyDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland. Eleanor.molloy@tcd.ie.

Funding

Health Research Board (HRB) CDA 2018-008Health Research Board (HRB) ILP-POR-2019-086HRB-NCHF (national childrens health foundation) NCHF-2017-002National Children's Research Centre (NCRC) NCRC18- D/18/7
6 · The paper itself

Abstract

Neonatal Encephalopathy (NE) is a clinical syndrome presenting as neurological dysfunction. Persistent dysregulated Inflammation is associated with NE and miRNA biomarkers may correlate with developmental outcomes. We investigated miR-20a, miR-20b, miR-93 and miR-532 expression at birth and childhood following Neonatal Encephalopathy (NE) as potential biomarkers of inflammation, brain development, and long-term outcomes. Blood samples were collected from neonates with NE (week 1 of life) and children post-NE (2-5 years of age) and compared to age-matched controls (Neonatal and paediatric). Whole blood was stimulated ex-vivo with lipopolysaccharide, and total RNA was extracted from serum. MiR-20a, miR-20b, miR-93 and miR-532 were identified by TaqMan

Indexed as

Brain DiseasesInfant, Newborn, DiseasesMicroRNAsBiomarkersBrainCase-Control StudiesChild DevelopmentChild, PreschoolFemaleFollow-Up StudiesHumansInfant, NewbornLipopolysaccharidesMaleRegistriesBiomarkersLipopolysaccharidesMicroRNAsMIRN20a microRNA, humanMIRN20b microRNA, humanMIRN532 microRNA, humanMIRN93 microRNA, humanBrain injuryMiRNAsNeonatal encephalopathy

Identifiers

PMID40830168
PMCPMC12365146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.