Flexibly actuated pneumatic extrusion with in-situ monitoring for direct ink writing of heterogeneous and pressure-vulnerable materials.

Chaiwuth Sithiwichankit, Setthibhak Suthithanakom, Kantawatchr Chaiprabha, Kai Melde, Ratchatin Chancharoen

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Chaiwuth SithiwichankitDepartment of Mechanical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.

Setthibhak SuthithanakomInstitute for Molecular Systems Engineering and Advanced Materials, Heidelberg University, Heidelberg, Germany.

Kantawatchr ChaiprabhaDepartment of Mechanical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.

Kai MeldeInstitute for Molecular Systems Engineering and Advanced Materials, Heidelberg University, Heidelberg, Germany.

Ratchatin ChancharoenDepartment of Mechanical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand. ratchatin.c@chula.ac.th.

Funding

Thailand Science Research and Innovation Fund, Chulalongkorn University IND_FF_68_209_2100_031

6 · The paper itself

Abstract

This study presents a novel piston-driven pneumatic extrusion system for direct ink writing (DIW), featuring flexible actuation and real-time monitoring of extrusion pressure. The design integrates the benefits of both pressure and feedrate control, achieving consistent linewidth while safeguarding pressure-sensitive materials such as cell-laden hydrogels. The system comprises a lightweight pneumatic syringe on the printhead and a stationary actuation unit, allowing efficient decoupling of motion and extrusion. Experiments demonstrate stable gelatin extrusion with a mean linewidth of 4.32 mm and a minimal increase ratio of 0.012 over printing distance. These findings show promise for advancing DIW with emerging soft materials, particularly in bioprinting and sustainable manufacturing.

Indexed as

BioprintingDirect ink writingFlexible actuationIn-situ monitoringMaterial extrusion

Identifiers

PMID40830160

DOI10.1038/s41598-025-15164-9

PMCPMC12365064

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.