ArticleSignal transduction and targeted therapy2025
F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair.
Abstract read
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Article in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Tissue engineering for traumatic spinal cord injury: Research advances and clinical translation.Bioactive materials · 2026Review
- Multi-omics prediction of key proteases regulating scar formation and neural repair after spinal cord injury.Neural regeneration research · 2026Article
- Neonatal small extracellular vesicle-loaded GelNB hydrogel reprograms the vascular-immune microenvironment for spinal cord injury repair.Bioactive materials · 2026Article
- Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar-Limited Repair in Adult Spinal Cord Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Screening the optimal rTSMS frequency to orchestrate immune-fibrotic remodeling for adult spinal cord repair.Frontiers in neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Xu Xu *Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Feng Gao *Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Qixin Chen *Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Bairu Chen *Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Wenyu LiangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Runzhi HuangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Yuchen LiuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Zhibo LiuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Yanjing ZhuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Gufa LinKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Bei MaKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Letao YangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Shaorong GaoFrontier Science Center for Stem Cell Research, Tongji University, Shanghai, China. gaoshaorong@tongji.edu.cn.ORCID 0000-0003-1041-3928
Rongrong ZhuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China. rrzhu@tongji.edu.cn.ORCID 0000-0002-3955-5965
Liming ChengKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, School of Medicine, Tongji Hospital affiliated with Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China. limingcheng@tongji.edu.cn.
Funding
National Natural Science Foundation of China (National Science Foundation of China) 82001308National Natural Science Foundation of China (National Science Foundation of China) 82225027National Natural Science Foundation of China (National Science Foundation of China) 82271418National Natural Science Foundation of China (National Science Foundation of China) 82271419National Natural Science Foundation of China (National Science Foundation of China) 82330062National Natural Science Foundation of China (National Science Foundation of China) 92468204
Abstract
Scarring is an insurmountable obstacle for axonal regeneration in recovery from spinal cord injury (SCI). It impedes the repair effects of therapeutic targets in cortical neurons, such as PTEN
Indexed as
CicatrixF-Box ProteinsMicrogliaSpinal Cord InjuriesAdenosineAnimalsAxonsHumansMiceNerve RegenerationAdenosineF-Box ProteinsN-methyladenosine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.