ArticleACS nano2025
Economical and Versatile Subunit Design Principles for Self-Assembled DNA Origami Structures.
Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- From Blueprint to Breakthrough: How Far Can We Fold DNA Origami for Nano-Enabled Technologies?JACS Au · 2026Review
- Design and Application of Hetero-Multicomponent Metal Oxide Photocatalysts for Wastewater Treatment: Ti-Cu-Zn Catalysts and Future Research Directions.Molecules (Basel, Switzerland) · 2026Review
- Modular programming of interaction and geometric specificity enables assembly of complex DNA origami nanostructures.Nature communications · 2025Article
- Measuring multisubunit mechanics of geometrically programmed colloidal assemblies via cryo-EM multi-body refinement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a modular design approach for creating versatile DNA origami subunits that can target diverse self-assembled structures. The subunit consists of a constant "core module" with variable "bond modules" and "angle modules" added to its exterior, controlling interaction specificity, strength, and structural geometry. The design features flexible joints between subunits, implemented by using single-stranded angle modules, whose mechanical properties and possible conformations are characterized by cryogenic electron microscopy and coarse-grained molecular modeling. We demonstrate the design's versatility through the assembly of structures with different Gaussian curvature, including sheets, spherical shells, and tubes. Our findings suggest that incorporating a judicious amount of flexibility in the bonds provides error tolerance in design and fabrication while maintaining target fidelity. Furthermore, off-target assemblies potentially introduced by flexibility can be counterbalanced by increasing the number of distinct bonds. This approach enables precise targeting of specific structural binding angles across a broad range of configurations by eliminating unfavorable interactions.
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Registered trials
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