SynthesisThe Journal of clinical endocrinology and metabolism2025
Diagnostic Efficiency of Thyroglobulin in Lymph Node Fine-needle Aspiration Washout: A Systematic Review and Meta-analysis.
Synthesis in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Efficiency of Thyroglobulin in Lymph Node Fine-needle Aspiration Washout: A Systematic Review and Meta-analysis.The Journal of clinical endocrinology and metabolism · 2025Pooled it
- Refining CT Use Before Active Surveillance in Papillary Thyroid Microcarcinoma.Korean journal of radiology · 2026Article
- Antibody-Stratified FNA-Thyroglobulin Cut-Off Values for Preoperative Lymph Node Assessment in Differentiated Thyroid Cancer.Diagnostics (Basel, Switzerland) · 2026Article
- Preoperative diagnosis of lateral cervical lymph node metastasis in papillary thyroid carcinoma: a multimodal ultrasound model integrating super-resolution ultrasound.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Predictive value and clinical guidance of FNA-Tg combined with BRAF V600E for PTC cervical lymph node metastasis: a case report.Frontiers in surgery · 2026Article
- Establishment and clinical performance evaluation of the thyroglobulin colloidal gold immunochromatographic assay.Frontiers in oncology · 2026Article
- Article
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4 authors.
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Abstract
contextCervical lymph node metastases are common in papillary thyroid carcinoma (PTC), causing recurrence and poor regional control, highlighting the need for accurate diagnostics. Although fine-needle aspiration with thyroglobulin washout (FNA-Tg) shows promise, its diagnostic performance and association with serum biomarkers across settings remain unclear.
objectiveTo assess the diagnostic performance of FNA-Tg for cervical lymph node metastases in PTC and its correlation with serum thyroglobin (s-Tg) and s-Tg antibody (s-Tg-Ab) levels. DATA SOURCES: PubMed, Embase, Web of Science, Scopus, Cochrane Library, and Ovid Medline were searched for relevant studies. STUDY SELECTION: Studies enrolling PTC patients with cervical lymphadenopathy who underwent FNA-Tg pre- or postthyroidectomy were included. Studies involving non-PTC populations or lacking sufficient data for 2 × 2 diagnostic table construction were excluded. DATA EXTRACTION: Data were independently extracted by 3 researchers, and study quality was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 tool. DATA SYNTHESIS: FNA-Tg showed pooled sensitivity of 0.94 [95% confidence interval (CI), 0.91-0.96], specificity of 0.92 (95% CI: 0.88-0.94), and diagnostic odds ratio (DOR) of 174.20 (95% CI: 87.05-348.61), with an area under curve (AUC) of 0.98 (95% CI: 0.96-0.99). Postthyroidectomy, sensitivity increased to 0.96 (95% CI: 0.94-0.98), specificity to 0.93 (95% CI: 0.86-0.96), and DOR to 305.87 (95% CI: 127.99-730.93), with an AUC of 0.98 (95% CI: 0.97-0.99). In the group without thyroid gland present, sensitivity was 0.96 (95% CI: 0.93-0.97), specificity 0.93 (95% CI: 0.87-0.97), and DOR 300.27 (95% CI: 118.47-761.05), with an AUC of 0.98 (95% CI: 0.97-0.99). Likelihood ratio scattergrams and Fagan plots supported its discriminatory ability. FNA-Tg correlated weakly with s-Tg but not with s-Tg-Ab.
conclusionFNA-Tg showed high diagnostic accuracy, especially after thyroidectomy, with minimal s-Tg-Ab interference, supporting its role in PTC surveillance.
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