Evidence map›Paper›PMID 40829942›Full record

ArticleeNeuro2025

Selective Targeting of a Defined Subpopulation of Corticospinal Neurons Using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity.

Jake Lustig, Alexander Lammers, Julia Kaiser, Payal Patel, Aidan Raghu, James M Conner, Phong Nguyen, Eiman Azim, Vibhu Sahni

Abstract read
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jake LustigBurke Neurological Institute, White Plains, New York 10605.
Alexander LammersBurke Neurological Institute, White Plains, New York 10605.
Julia KaiserBurke Neurological Institute, White Plains, New York 10605.ORCID https://orcid.org/0000-0001-5142-6050
Payal PatelBurke Neurological Institute, White Plains, New York 10605.
Aidan RaghuBurke Neurological Institute, White Plains, New York 10605.
James M ConnerMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037.ORCID https://orcid.org/0000-0002-0731-8746
Phong NguyenMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037.
Eiman AzimMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037.ORCID https://orcid.org/0000-0002-1015-1772
Vibhu SahniBurke Neurological Institute, White Plains, New York 10605 vis2763@med.cornell.edu.ORCID https://orcid.org/0000-0002-6215-2232

Funding

Neurorehabilitation and Restorative Neuroscience NetworkK12HD093427 · NICHD · GEORGETOWN UNIVERSITY · PI BREGMAN, BARBARA S, DROMERICK, ALEXANDER W · 2017 to 2021
$3.9M
Neural control of skilled movements: an ethological dissection of genetically tractable mammalian motor circuitsDP2NS105555 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2017 to 2022
$3.7M
Transcriptional Regulation Over Neurogenesis of Cortical Output Neuron Segmental Identity and DiversityR01NS131662 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI Vibhu Vinodchandra Sahni · 2023 to 2026
$2.1M
NICHD NIH HHS K12 HD093427NINDS NIH HHS DP2 NS105555NINDS NIH HHS R01 NS131662
6 · The paper itself

Abstract

The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPNs) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular delineation enables prospective identification of corticospinal neurons (CSNs) projecting to thoraco-lumbar spinal segments; however, it remains unclear whether other SCPN subpopulations in developing sensorimotor cortex can be prospectively identified in this manner. Such molecular tools could enable investigations of SCPN circuitry with precision and specificity. During development, Kelch-like 14 (

Indexed as

NeuronsPyramidal TractsSensorimotor CortexAnimalsFemaleIntegrasesMaleMiceMice, Inbred C57BLMice, TransgenicIntegrasesbrainstem innervationcerebellinconditional AAV labelingcorticospinalCrim1Easi-CRISPRgenomic Cre reporterssegmental axon projection

Identifiers

PMID40829942
PMCPMC12418067

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.