ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Multivariate White Matter Microstructure Alterations in Older Adults with Coronary Artery Disease.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Advances in brain MRI for CAD-associated cognitive impairment with supplementary perspectives from traditional Chinese medicine.Frontiers in medicine · 2026Review
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16 authors.
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Abstract
Patients with coronary artery disease (CAD) face an increased risk of cognitive impairment, dementia, and stroke. While white matter (WM) lesions are frequently reported in patients with CAD, the effects on WM microstructure alterations remain largely unknown. We aimed to identify WM microstructural alterations in individuals with CAD compared with healthy controls (HC) and to examine their relationships with cognitive performance. Forty-three (43) patients with CAD (35 males and 8 females) and 36 HC (26 males and 10 females) aged 50 and older underwent comprehensive neuropsychological testing and multimodal 3 T magnetic resonance imaging (MRI). A novel multivariate approach-the Mahalanobis distance (D2)-was used to quantify WM abnormalities as the amount of deviation from the HC reference group. D2 integrates multiple MRI-derived diffusion-weighted imaging, R1 relaxometry, and magnetization transfer imaging metrics, while accounting for covariance between metrics. Relationships between WM D2 and cognition (executive function and processing speed) were also assessed. Compared with HCs, patients with CAD had higher D2 values in the whole WM (
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