Evidence map›Paper›PMID 40829932›Full record

ArticleLife science alliance2025

Bipartite chromatin recognition by Hop1 from two diverged Holozoa.

Alyssa A Rodriguez, Alessandro E Cirulli, Katie Chau, Justin Nguyen, Qiaozhen Ye, Kevin D Corbett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Alyssa A RodriguezDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Alessandro E CirulliDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Katie ChauDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Justin NguyenDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Qiaozhen YeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Kevin D CorbettDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA kcorbett@ucsd.edu.ORCID 0000-0001-5854-2388

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunityR35GM144121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett · 2022 to 2026
$2.7M
NIGMS NIH HHS K12 GM068524NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R35 GM144121
6 · The paper itself

Abstract

In meiosis, ploidy reduction is driven by a complex series of DNA breakage and recombination events between homologous chromosomes, orchestrated by meiotic HORMA domain proteins (HORMADs). Meiotic HORMADs possess a central chromatin binding region (CBR) whose architecture varies across eukaryotic groups. Here, we determine high-resolution crystal structures of the meiotic HORMAD CBR from two diverged aquatic Holozoa,

Indexed as

ChromatinDNA-Binding ProteinsSchistosoma mansoniAnimalsHistonesMeiosisNucleosomesProtein BindingChromatinDNA-Binding ProteinsHistonesNucleosomes

Identifiers

PMID40829932
PMCPMC12365614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.