Trial reportBMJ (Clinical research ed.)2025
Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Position Intervention to Reduce Hypoxemia in Sedation Patients
Effect of Semirecumbent and Lateral Positioning on Postoperative Hypoxemia : a Randomized Controlled Trial
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- European stroke organisation guideline on stroke-associated pneumonia.European stroke journal · 2026Guideline
- Effect of lateral positioning on ventilation in patients with blunt thoracic injury during pressure support ventilation: the VICTORY study.Intensive care medicine experimental · 2026Article
- Case Report: Awake lateral decubitus intubation for a patient with critical tracheal stenosis secondary to retrosternal goiter: salvaging a 2 mm airway without ECMO support.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the effect of lateral versus supine positioning on incidence of hypoxaemia in sedated patients and to provide evidence based recommendations for respiratory strategies.
designProspective, multicentre, randomised controlled trial.
setting14 tertiary hospitals in China, July to November 2024.
participants2159 adults (≥18 years) who underwent sedation.
interventionsSedated patients were randomly assigned (1:1) to receive either lateral positioning or conventional supine positioning, stratified by study centres.
main outcome measuresThe primary outcome was incidence of hypoxaemia (peripheral oxygen saturation (SpO
resultsOf 2159 patients randomised, 2143 were included in the primary analysis. The mean age of the patients was 53.1 years, mean body mass index was 23.9, and 53.7% (1150/2143) were women. The incidence of hypoxaemia was significantly lower in the lateral group compared with supine group (5.4% (58/1073)
conclusionsPlacing sedated adults in the lateral position significantly reduces the incidence and severity of hypoxaemia and decreases the need for airway rescue interventions without compromising safety. Given its simplicity and low cost, lateral positioning could offer advantages in remote or resource constrained clinical settings. Further replication studies targeting patients with advanced age and high body mass index are needed to improve the generalisability of the findings.
trial registrationClinicalTrials.gov NCT06459167.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.