ArticleJournal of clinical pathology2025
Relationship between adenovirus infection and intussusception via pathological evidence confirms.
Article in Journal of clinical pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Research progress on the association between lymphoid hyperplasia and intussusception in the terminal ileum of children.Frontiers in pediatrics · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlthough some cases of intussusception in older children are associated with pathological changes such as lymphoma or polyps, the cause of most cases in infants is unknown. Several reports have identified an association between adenovirus infection and intussusception in children. However, much of the evidence is indirect, such as stool samples or throat swab data. Our study analysed intestinal tissue, which may be more direct evidence of the relationship between adenovirus infection and intussusception.
methodsWe retrospectively reviewed children<6 years of age with intussusception who underwent surgery for failed reduction. The pathological tissue was processed into formalin-fixed paraffin-embedded (FFPE) sections. Adenovirus immunohistochemistry (IHC) and PCR testing were performed to obtain direct evidence of the relationship between adenovirus infection and intussusception.
resultsOur study included 29 patients, 27 appendiceal and 8 intestinal tissues. Only eight appendix specimens were successfully processed into FFPE tissue. IHC testing was positive in three cases (37.5%), and PCR testing was positive for adenovirus type C in four cases (50%). The control group consisted of eight children <6 years who underwent incidental appendectomies, and all control subjects had negative IHC and PCR analyses. PCR is as useful and reliable as IHC in diagnosing adenovirus in intussusception and has greater sensitivity than IHC.
conclusionWe directly confirmed the relationship between adenovirus infection and intussusception through IHC analysis and PCR detection of pathological evidence. PCR is more sensitive than IHC for diagnosing adenovirus in intussusception.
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