ArticleJournal of clinical periodontology2025
Saliva Versus All-Site Microbiome and Proteome Mapping in Periodontitis.
Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Systemic Antibiotics in the Surgical Treatment of Peri-Implantitis: Impact on the Salivary Microbiome.Journal of clinical periodontology · 2026Trial
- Shotgun metagenomic mapping of saliva reveals insights into diversity and function of the oral microbiome in pregnancy.Scientific reports · 2026Article
- Potential biomarkers for early periodontal inflammation: investigating CD5Scientific reports · 2026Article
- Periodontal disease-associated oral and gut microbiome changes in female rheumatoid arthritis patients.BMC oral health · 2026Article
- Comparative Analysis of Oral Microbiome in Indian Type 2 Diabetes Mellitus (T2DM) and Periodontitis Cohorts.Diseases (Basel, Switzerland) · 2026Article
- Salivary microbial profiles across periodontal severity stage according to the 2018 AAP/EFP classifications: a cross-sectional study.Frontiers in oral health · 2026Article
- Anaerobic stress index to predict microbial ecological shifts in clear aligners.Journal of oral microbiology · 2026Article
- Association between oral microbial shifts and polycystic ovary syndrome: a systematic review.Journal of oral microbiology · 2026Review
- Saliva Versus All-Site Microbiome and Proteome Mapping in Periodontitis.Journal of clinical periodontology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimSaliva is a diagnostic surrogate for microbial and host biomarkers in periodontitis, but whether it reflects subgingival plaque, gingival crevicular fluid (GCF) or serum remains debated. This study profiled GCF and subgingival plaque from all sites of periodontitis patients, comparing them to saliva and serum. MATERIALS AND
methodsSaliva, serum, subgingival plaque and GCF were obtained from three patients with stage III, grade C periodontitis, having 23, 25 and 27 teeth, respectively, with six sites sampled per tooth. All plaque and GCF samples were pooled per patient. Shotgun sequencing and mass spectrometry proteomics were used for microbiome and proteome analysis, respectively.
resultsTotally 277 microbial taxa were collectively identified in saliva and plaque, 93 of which were differentially abundant between the two. Saliva exhibited higher overall species diversity, but lower periodontal pathogen abundance. A total of 1153 host proteins were identified (saliva: 803; GCF: 932; serum: 195) across the three biological fluids, with 685 shared among saliva and GCF and 109 among all three. Saliva contained slightly fewer proteins than GCF, but shared several common immune, metabolic and enzyme regulation pathways.
conclusionSaliva is effective for broad microbiome and proteome screening; whereas plaque delivers greater precision in identifying specific periodontal pathogens directly associated with a periodontal pocket.
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