ArticleBMJ open2025
Effects of ciprofol on postoperative delirium and outcomes in older patients undergoing major thoracic surgery: protocol for a multicentre, prospective, single-blinded, randomised controlled study.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06674226 (Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery: a Multicentre, Prospective, Single-blind, Randomized Controlled Study
Who cites it
1 citing paper in PubMed.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPostoperative delirium (POD) is a notable complication in older adults undergoing major thoracic surgery and is associated with poor clinical outcomes. Ciprofol, an innovative sedative known for its haemodynamic stability, holds the potential to lower the risk of POD. However, high-quality evidence supporting this claim is limited. The objective of this study is to evaluate the effect of ciprofol compared with propofol on the incidence of POD and postoperative outcomes in older patients undergoing thoracic surgeries. METHODS AND ANALYSIS: This multicentre, prospective, single-blinded, randomised controlled trial will recruit patients aged ≥65 years scheduled for elective thoracoscopic lobectomy or segmentectomy, with an anticipated anaesthesia duration of at least 2 hours. Participants will be randomised to receive either ciprofol (0.25-1.5 mg/kg/hour) or propofol (1-6 mg/kg/hour) in a 1:1 ratio. The primary outcome is the incidence of POD within 7 days postoperatively, assessed via the three-dimensional confusion assessment method. Secondary outcomes include emergence delirium assessed using the confusion assessment method for the intensive care unit, the incidence of combined adverse events during induction and maintenance of anaesthesia, duration of intraoperative hypotension, minimum mean intraoperative arterial pressure, duration of Wavelet Index <40, other adverse events identified during the follow-up period, length of stay, first exhaust time and postoperative first time to taking food. A non-inferiority margin of 5% is applied for sample size calculation, yielding a total of 214 participants, adjusted for a 10% attrition rate. ETHICS AND DISSEMINATION: Approval on ethical grounds has been received from the ethics committee of Xuanwu Hospital, Capital Medical University (LinYanShen (2024)-NO.201-003-Revised V.1). We will publish the findings in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT06674226.
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