ArticleJournal of advanced research2026
SIRPα extracellular domain shed from neutrophils by ADAM10 aggravates sepsis via initiating nitric oxide release from erythrocyte.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- SIRPα Cleavage Is Associated with Inflammatory Response, Corticosteroid Nonresponse, and Worse Prognosis in Clinical and Preclinical Models of Alcohol-Associated Hepatitis.The American journal of pathology · 2026Article
- Decoding meningioma prognosis with multi-omics: macrophage diversity, immune-CNV interplay, and novel SPP1-targeted strategies.Journal of neuro-oncology · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSepsis is a life-threatening condition with a high mortality rate, yet its underlying mechanisms remain incompletely understood.
objectivesThis study investigates the role of the cleaved extracellular domain of signal regulatory protein alpha (SIRPα-ex) in the pathogenesis of sepsis.
methodsThe presence of shed SIRPα-ex was examined in the circulation of septic mice and patients. Functional assays involved neutralization of SIRPα-ex with an anti-SIRPα antibody and administration of recombinant SIRPα-ex-Fc in a murine sepsis model. Genetic models, including Sirpα
resultsWe found that Sirpα
conclusionThese findings identify shedding SIRPα-ex as a key exacerbating factor in sepsis via NO-mediated vascular dysfunction. Targeting SIRPα-ex shedding offers a potential therapeutic strategy for mitigating sepsis.
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Registered trials
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