ArticleOpen biology2025
Systemic analyses show that the biosynthesis and spatial distribution of fatty acids, triglycerides and lipids differed in male and female mice and humans.
Article in Open biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Associations of plasma inosine with lipid parameters in a biracial community cohort.Clinical nutrition (Edinburgh, Scotland) · 2025Trial
- Systemic analyses show that the biosynthesis and spatial distribution of fatty acids, triglycerides and lipids differed in male and female mice and humans.Open biology · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
Recent work has shown that the prevalence and character of metabolic diseases differs between male and female mammals. This strongly suggests that the control mechanisms that govern, for example lipid metabolism, differ between the sexes. If true, a one-size-fits-all approach to treating metabolic disease will not be effective in all patients. We tested three hypotheses to understand how the lipid metabolism of male and female mammals may differ. First, whether endogenous fatty acid biosynthesis differed between tissues in the same male and female mice. Second, whether the system-level control of lipid pathways differed between the sexes. Third, whether lipid composition differs between males and females at a population level. We found that fatty acid biosynthesis was distinct in male and female mice across tissues. Systemic control of phospholipid and triglyceride metabolism also differed between the sexes. A human population showed that both phospholipid and triglyceride metabolism differed between males and females.
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