Evidence map›Paper›PMID 40829600›Full record

ArticleAmerican journal of human genetics2025

Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.

Michael J Betti, James Jaworski, Shilin Zhao, J Sunil Rao, Bríd M Ryan, Ann G Schwartz, Christine M Lusk, Lucie McCoy, John K Wiencke, Marino A Bruce and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Lung cancer screening: are race- and risk-aware criteria needed?Journal of the National Cancer Institute · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michael J BettiDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
James JaworskiDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Shilin ZhaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
J Sunil RaoDepartment of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, MN 55414, USA.
Bríd M RyanLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ann G SchwartzKarmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
Christine M LuskKarmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
Lucie McCoyDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
John K WienckeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Marino A BruceDepartment of Behavioral and Social Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX 77021, USA.
Stephen ChanockDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Eric R GamazonDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jacklyn N HellwegeDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Melinda C AldrichDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: melinda.aldrich@vumc.org.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
BIOMARKERS OF LUNG CANCER SUSCEPTIBILITY IN MINORITIESR01ES006717 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 1994 to 2009
$8.9M
Inflammation Pathways and COPD in the Development of Lung CancerR01CA141769 · NCI · WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G. · 2011 to 2016
$8.7M
Understanding determinants of racial disparities in lung cancer incidenceU01CA253560 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALDRICH, MELINDA · 2020 to 2023
$2.3M
NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS P30 CA022453NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA141769NCI NIH HHS U01 CA202979NCI NIH HHS U01 CA253560NIEHS NIH HHS R01 ES006717
6 · The paper itself

Abstract

Striking disparities in lung cancer exist, with Black/African American individuals disproportionately affected by lung cancer, yet the genetic architecture in African ancestry individuals is poorly understood. We aimed to address this by performing a comprehensive genetic association study of lung cancer, incorporating local ancestry, across 6,490 African ancestry individuals (2,390 individuals with lung cancer and 4,100 control subjects). We identified a single genome-wide significant (p < 5 × 10

Indexed as

Black PeopleGenetic Predisposition to DiseaseLung NeoplasmsCase-Control StudiesFemaleGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideWhiteadmixtureAfrican ancestryGWASlocal ancestrylung cancerTWAS

Identifiers

PMID40829600
PMCPMC12461003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.