Evidence map›Paper›PMID 40829484›Full record

ReviewJournal of critical care2026

Antimicrobial-coated endotracheal tubes: A narrative review.

Abigail K Richardson, Robert G Fuller, Michael D April, Julie A Rizzo, David J Douin, Margaret M Moran, Matthew D Smith, Vikhyat S Bebarta, Steven G Schauer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abigail K RichardsonUniformed Services University of the Health Sciences F. Edward Hebert School of Medicine, Bethesda, MD, USA.
Robert G FullerUniversity of Colorado School of Medicine, Aurora, CO, USA; Center for Combat and Battlefield (COMBAT) Research, University of Colorado School of Medicine, Aurora, CO, USA.
Michael D AprilUniformed Services University of the Health Sciences F. Edward Hebert School of Medicine, Bethesda, MD, USA; Department of Emergency Medicine, Brooke Army Medical Center, JBSA Fort Sam Houston, TX, USA.
Julie A RizzoUniformed Services University of the Health Sciences F. Edward Hebert School of Medicine, Bethesda, MD, USA; Department of Surgery, Brooke Army Medical Center, JBSA Fort Sam Houston, TX, USA.
David J DouinDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.
Margaret M MoranDepartment of Emergency Medicine, Brooke Army Medical Center, JBSA Fort Sam Houston, TX, USA.
Matthew D SmithDepartment of Anesthesiology, Brooke Army Medical Center, JBSA Fort Sam Houston, TX, USA.
Vikhyat S BebartaDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA; Center for Combat and Battlefield (COMBAT) Research, University of Colorado School of Medicine, Aurora, CO, USA.
Steven G SchauerDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA; Center for Combat and Battlefield (COMBAT) Research, University of Colorado School of Medicine, Aurora, CO, USA; US Army Medical Center of Excellence, JBSA Fort Sam Houston, TX, USA. Electronic address: steven.schauer@cuanschutz.edu.

Funding

Restoring Endothelial Function After Traumatic Injury to Reduce ARDS and Multi-Organ DysfunctionK23HL165107 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI David J. Douin · 2023 to 2026
$759k
NHLBI NIH HHS K23 HL165107
6 · The paper itself

Abstract

introductionVentilator-associated pneumonia (VAP) is a significant source of morbidity and mortality. We sought to assess the current evidence on antimicrobial-coated endotracheal tubes (ETT) as one potential tool to break the cycle of colonization and infection among ICU patients.

methodsWe conducted a narrative review of available studies focused on the use of antimicrobial-coated ETTs to reduce VAP. The selection process adhered to PRISMA-ScR guidelines.

resultsA total of 58 studies met the inclusion criteria. Silver-based coatings were the most common, with 15 studies, including three randomized controlled trials and two systematic reviews. Of the 15 studies, 12 demonstrated a reduction in bacterial colonization. Two demonstrated delay of VAP onset and three demonstrated reduced VAP incidence. While one study determined there was a decreased mortality, three others determined no statistically significant difference could be proven in overall mortality, hospital stay. Additional research explored coatings composed of a noble metal alloy, zinc, selenium, antibiotics, biocides, and biomimetics. Novel surface modifications such as nano-roughening, micro-patterning, and photodynamic agents showed promise in preventing biofilm formation, though clinical validation remains limited.

conclusionsMany antimicrobial materials have undergone in vitro appraisal as potential ETT coatings to reduce VAP incidence, but only silver has been extensively tested in RCTs.

Indexed as

Anti-Infective AgentsCoated Materials, BiocompatibleIntubation, IntratrachealPneumonia, Ventilator-AssociatedBiofilmsHumansIntensive Care UnitsAnti-Infective AgentsCoated Materials, BiocompatibleAntimicrobialbacteriaEndotrachealNoblePneumoniaTubeVentilator

Identifiers

PMID40829484
PMCPMC12643042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.