Evidence map›Paper›PMID 40829214›Full record

ReviewCurrent opinion in microbiology2025

Structure, function, and quantitative biology of the Drosophila gut microbiome.

William B Ludington, Haolong Zhu, Kevin Aumiller, Angela Xu, Josh Derrick

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. RNAi of the electron transport chainmicroPublication biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

William B LudingtonDepartment of Biosphere Sciences and Engineering, Carnegie Institution for Science, Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: will.ludington@gmail.com.
Haolong ZhuDepartment of Biosphere Sciences and Engineering, Carnegie Institution for Science, Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Kevin AumillerDepartment of Biosphere Sciences and Engineering, Carnegie Institution for Science, Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Angela XuDepartment of Biosphere Sciences and Engineering, Carnegie Institution for Science, Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Josh DerrickDepartment of Biosphere Sciences and Engineering, Carnegie Institution for Science, Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

Funding

Host mechanisms of gut colonization by commensal bacteria that affect lifespanR01DK128454 · NIDDK · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI LUDINGTON, WILLIAM BASIL · 2022 to 2024
$1.2M
Serine-rich repeat proteins in evolution of Lactobacillus-host specificityR21AI173779 · NIAID · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI LUDINGTON, WILLIAM BASIL · 2023 to 2024
$452k
NIAID NIH HHS R21 AI173779NIDDK NIH HHS R01 DK128454
6 · The paper itself

Abstract

Drosophila melanogaster is one of the most powerful animal models for developmental genetics, and it has a relatively simple microbiome. Flies can easily be reared germ-free, then reassociated with defined microbial strains to study colonization and bacterial effects on the fly, making a highly tractable model for microbiome studies. This review provides a biological background on the Drosophila microbiome for quantitative researchers interested in using the system. We discuss the current understanding of which microbes compose the fly gut microbiome, how they colonize, how they affect the fly, and how the overall microbiome structure influences its function. We also discuss existing large data sets and quantitative theory of the Drosophila microbiome.

Indexed as

BacteriaDrosophila melanogasterGastrointestinal MicrobiomeGastrointestinal TractAnimals

Identifiers

PMID40829214
PMCPMC12440575

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.