Evidence map›Paper›PMID 40829199›Full record

ArticleCarbohydrate research2025

Synthesis of disaccharide and trisaccharide substructures of an A. baumannii lipooligosaccharide core.

Brandon J Conrad, James M Armstrong, Shaofu Du, Varad Agarkar, Lebogang Kgoadi, Alex Wexler, Justin R Ragains

Abstract read
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In one paragraph

Article in Carbohydrate research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brandon J ConradDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70806, USA.
James M ArmstrongDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70806, USA.
Shaofu DuDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70806, USA.
Varad AgarkarDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70806, USA.
Lebogang KgoadiDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70806, USA.
Alex WexlerDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70806, USA.
Justin R RagainsDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70806, USA. Electronic address: jragains@lsu.edu.

Funding

Synthesis of Lipooligosaccharide-Capsular Polysaccharide Conjugates for the Prevention and Treatment of Infections Caused by Acinetobacter baumanniiR15AI140226 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI RAGAINS, JUSTIN ROBERT · 2019 to 2019
$431k
Synthesis and Evaluation of a Bivalent Glycoconjugate Vaccine for Prevention of Infection with Acinetobacter baumanniiR21AI182953 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI RAGAINS, JUSTIN ROBERT · 2024 to 2025
$419k
NIAID NIH HHS R15 AI140226NIAID NIH HHS R21 AI182953
6 · The paper itself

Abstract

Identification and synthesis of highly conserved glycans is a priority for understanding chemical immunology as it applies to drug-resistant pathogens such as Gram-negative Acinetobacter baumannii. Herein, we report on our initial efforts aimed toward the synthesis of a highly conserved lipooligosaccharide core isolated originally from A. baumannii ATCC 19606. Key steps in the syntheses include a regioselective acetonide cleavage and a stereoselective and regioselective O-glycosylation of the 4-position of the 8-carbon sugar "Kdo."

Indexed as

Acinetobacter baumanniiDisaccharidesLipopolysaccharidesTrisaccharidesCarbohydrate ConformationCarbohydrate SequenceGlycosylationStereoisomerismDisaccharideslipid-linked oligosaccharidesLipopolysaccharidesTrisaccharidesAcinetobacter baumanniiDrug-resistant bacteriaMultistep synthesisOligosaccharides

Identifiers

PMID40829199
PMCPMC12416160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.